Table 1 Critical appraisal of animal model studies
From: An alternative pathway for preclinical research in fluid management
Study selection |
   Indication (eg sepsis) |
   Category |
Pathophysiology |
Therapy |
Other |
Study assessment |
   Validity of results |
Randomization |
Accounting for all experimental subjects |
Blinding |
Comparability of groups at baseline |
Lack of confounders |
   Specific findings |
Effect size |
Precision |
   Generalizability to corresponding clinical indication |
Clinical relevance of animal model |
Supportive therapies similar to those in the clinical setting |
Consideration of intercurrent illness |
Species specificity of the model |
Potential cost-effectiveness |
Evidence-based recommendations |
   Strength of evidence |
   Quality of evidence |