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Table 1 Baseline characteristics of patients with and without sepsis*

From: Correction: Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial

 

Patients with sepsis

Patients without sepsis

Variable

DEX (n = 31)

LZ (n = 32)

DEX (n = 21)

LZ (n = 19)

Age

60 (46, 65)

58 (44, 66)

61 (50, 68)

60 (52, 67)

Males

58%

41%

57%

53%

APACHE II

30 (26, 34)

29 (24, 32)

27 (20, 31)

25 (20, 30)

SOFA score

10 (9,13)

9 (8, 12)

9 (8, 12)

8 (7, 9)

IQCODE at enrollment

3 (3, 3)

3 (3, 3)

3 (3, 3)

3 (3, 3)

Medical ICU

77%

81%

62%

47%

Surgical ICU

23%

19%

38%

53%

Pre-enrollment lorazepam (mg)

1.5 (0, 5)

0 (0, 4)

0 (0, 4)

0 (0, 2)

Enrollment RASS

-3 (-4, -2)

-4 (-4, -3)

-3 (-4, 0)

-3 (-4, -1)

SIRS criteria

    

   Temperature (Fahrenheit)

37.5 (37, 38.3)

38 (37.2, 38.6)

36.7 (35.8, 37.8)

37.2 (36.2, 38.3)

   White blood count (103/μL)

12.5 (6.6, 21.7)

12.5 (7.7, 18.8)

14.6 (8.9,17.9)

10 (7.5,14)

   Systolic BP (mm Hg)

88 (78, 100)

83 (79, 100)

92 (90, 100)

90 (80,110)

   Heart rate (per minute)

113 (100, 134)

119 (96, 130)

80 (65,123)

107 (99, 126)

   Respiratory rate

26 (20, 33)

33 (27, 39)

20 (15, 24)

24 (20,28)

Organ dysfunction at enrollment

    

   PaO2/FiO2 ratio

128 (105, 209)

126 (94, 198)

127 (72, 211)

145 (81, 223)

   Creatinine (mg/dL)

1.7 (0.8, 2.9)

1.0 (0.8, 1.8)

1.2 (1.0, 1.7)

0.9 (0.8, 1.4)

   Vasopressors

32%

56%

19%

5%

   Bilirubin (mg/dL)

0.5 (0.4, 0.8)

0.9 (0.4, 1.8)

0.6 (0.5, 1.6)

0.6 (0.4, 1.1)

   Platelets (103/μL)

176 (61, 304)

183 (107, 266)

186 (101,242)

145 (114, 242)

  1. Median (interquartile range) unless otherwise noted
  2. *Abbreviations: DEX, dexmedetomidine; LZ, lorazepam; APACHE II, Acute Physiology and Chronic Health Evaluation II; SOFA, Sequential Organ Failure Assessment; IQCODE, Informant Questionnaire on Cognitive Decline in the Elderly; ICU, intensive care unit; SIRS, Systemic Inflammatory Response Syndrome; BP, Blood pressure.