| Patients with sepsis | Patients without sepsis | ||
---|---|---|---|---|
Variable | DEX (n = 31) | LZ (n = 32) | DEX (n = 21) | LZ (n = 19) |
Age | 60 (46, 65) | 58 (44, 66) | 61 (50, 68) | 60 (52, 67) |
Males | 58% | 41% | 57% | 53% |
APACHE II | 30 (26, 34) | 29 (24, 32) | 27 (20, 31) | 25 (20, 30) |
SOFA score | 10 (9,13) | 9 (8, 12) | 9 (8, 12) | 8 (7, 9) |
IQCODE at enrollment | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) |
Medical ICU | 77% | 81% | 62% | 47% |
Surgical ICU | 23% | 19% | 38% | 53% |
Pre-enrollment lorazepam (mg) | 1.5 (0, 5) | 0 (0, 4) | 0 (0, 4) | 0 (0, 2) |
Enrollment RASS | -3 (-4, -2) | -4 (-4, -3) | -3 (-4, 0) | -3 (-4, -1) |
SIRS criteria | Â | Â | Â | Â |
   Temperature (Fahrenheit) | 37.5 (37, 38.3) | 38 (37.2, 38.6) | 36.7 (35.8, 37.8) | 37.2 (36.2, 38.3) |
   White blood count (103/μL) | 12.5 (6.6, 21.7) | 12.5 (7.7, 18.8) | 14.6 (8.9,17.9) | 10 (7.5,14) |
   Systolic BP (mm Hg) | 88 (78, 100) | 83 (79, 100) | 92 (90, 100) | 90 (80,110) |
   Heart rate (per minute) | 113 (100, 134) | 119 (96, 130) | 80 (65,123) | 107 (99, 126) |
   Respiratory rate | 26 (20, 33) | 33 (27, 39) | 20 (15, 24) | 24 (20,28) |
Organ dysfunction at enrollment | Â | Â | Â | Â |
   PaO2/FiO2 ratio | 128 (105, 209) | 126 (94, 198) | 127 (72, 211) | 145 (81, 223) |
   Creatinine (mg/dL) | 1.7 (0.8, 2.9) | 1.0 (0.8, 1.8) | 1.2 (1.0, 1.7) | 0.9 (0.8, 1.4) |
   Vasopressors | 32% | 56% | 19% | 5% |
   Bilirubin (mg/dL) | 0.5 (0.4, 0.8) | 0.9 (0.4, 1.8) | 0.6 (0.5, 1.6) | 0.6 (0.4, 1.1) |
   Platelets (103/μL) | 176 (61, 304) | 183 (107, 266) | 186 (101,242) | 145 (114, 242) |