Table 2 Comparison of patient populations in VA/NIH ATN and RENAL studies

Number

1,124

1,508

Age, years

59.7

64.5

Percentage of males

70.6%

64.6%

CKD classification^a

   0-2

61.0%

68.6%

   3a

21.1%

9.7%

   3b

11.0%

10.4%

   4

Excluded

11.3%

   5

Excluded

Excluded

Sepsis

63.0%

47.9%

Mechanical ventilation

80.6%

73.9%

Illness severity score

APACHE II: 26.4

APACHE III: 102.4

Total SOFA score (respiratory, cardiovascular, liver, coagulation)

7.55

7.40

Modalities of RRT

CVVHDF, SLEDD, or IHD

CVVHDF

RRT prior to randomization

64.3% (only patients who had undergone fewer than two sessions of IHD or SLEDD or less than 24 hours CRRT were included)

0% (patients with prior RRT excluded)

Commenced on CRRT

69.7%

100%

CRRT mode

Pre-dilution CVVHDF

Post-dilution CVVHDF

CRRT high-dose effluent target

35 mL/kg per hour

40 mL/kg per hour

CRRT low-dose effluent target

20 mL/kg per hour

25 mL/kg per hour

Time from ICU admission to first study RRT

6.7 days

2.1 days

Urea at study enrolment

23.8 mmol/L

24.2 mmol/L

Achieved dose of CRRT (high dose)

27.1 mL/kg per hour^b

33.4 mL/kg per hour

Achieved dose of CRRT (low dose)

17.5 mL/kg per hour^b

22 mL/kg per hour

Mean daily urea on CRRT (high dose)

11.7 mmol/L

12.7 mmol/L

Mean daily urea on CRRT (low dose)

16.8 mmol/L

15.9 mmol/L

Daily fluid balance on therapy

+130 mL

-20 mL

Survival at day 60

47.5%

Not reported

Survival at day 90

Not reported

55.3%

Percentage of survivors dependent on RRT

   At day 28

45.2%

13.3%

   At day 60

24.6%

Not reported

   At day 90

Not reported

5.6%