Table 2 Amphotericin-B nephrotoxicity; data cited in 2009 Infectious Disease Society of America guidelines [1]
From: Treatment of candidemia in adult patients without neutropenia - an inconvenient truth
Wingard et al. [12] | Bates et al. [11] | |
|---|---|---|
Year of publication | 1999 | 2001 |
Data collection | Jan 1991 to Dec 1993 | May 1993 to Apr 1997 |
Inclusion criteria | 1. Allogeneic BMT 2. Autologous BMT 3. Solid organ transplantation 4. Immunosuppressive conditions not related to transplantation | Not patients but number of admissions; at least 156 repeated measurements; major violation of the assumptions of statistical methods used |
Infection | Aspergillosis | Unknown |
Duration of AmB (days) | 20.4 | 14.8 |
AmB cumulative dose (g) | Unknown | 0.93 |
AmB daily dose (mg/kg) | Unknown | Unknown |
Concomitant nephrotoxic agents | 87% | Collected (not given) |
Risk of death | HD >3× | ARF >6.6× |