Table 1 Infectious Disease Society of America guidelines for the treatment of candidemia in non-neutropenic adult patients [1, 2]
From: Treatment of candidemia in adult patients without neutropenia - an inconvenient truth
2004 | 2009 | |
|---|---|---|
Recommended therapy | AmB-d 0.6 to 1 mg/kg/day Fluconazole 400 to 800 mg/day Caspofungin 50 mg/day (70 mg first dose) | Echinochandina: Caspofungin 50 mg/day (70 mg first dose) Anidulafungin 100 mg/day (200 mg first dose) Micafungin 100 mg/day Fluconazol 6 mg/kg/day (12 mg/kg first dose) |
Alternative therapy | AmB-d 0.7 mg/kg/day + Fluconazol 800 mg/day (4 to 7 days, then Fluconazol 800 mg/day) | LF-AmB 3 to 5 mg/kg/day AmB-d 0.5 to 1 mg/kg Voriconazol 3 mg/kg bid (6 mg/kg first two doses) |
Duration of therapy | At least 14 days after last positive blood culture | At least 14 days after last positive blood culture |
Other recommendations | Removal of central venous catheter Ophthalmological evaluation | Removal of central venous catheter Ophthalmological evaluation |