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Table 4 Associations between TOLLIP haplotypes and sepsis susceptibility

From: Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population

  

Frequency

    

LD block

Haplotype a

Healthy control

Sepsis

P value

P adj value

OR (95% CI)

OR adj (95% CI)

Block 1b

Global test

  

0.127

0.244

  
 

GGAG

0.615

0.558

0.027

0.041

0.79 (0.65-0.97)

0.86 (0.72-0.98)

 

AAGA

0.225

0.215

0.636

0.768

0.94 (0.74-1.20)

0.98 (0.80-1.44)

 

GGGG

0.060

0.083

0.088

0.177

1.41 (0.95-2.10)

1.03 (0.80-2.32)

Block 2c

Global test

  

0.00018

0.00049

  
 

GTC

0.380

0.299

0.00085

0.0012

0.69 (0.56-0.86)

0.73 (0.62-0.89)

 

GTT

0.283

0.302

0.399

0.424

1.10 (0.88-1.38)

1.06 (0.80-1.34)

 

ATT

0.248

0.261

0.590

0.778

1.07 (0.85-1.35)

1.02 (0.79-1.32)

 

GCT

0.076

0.134

0.00028

0.00092

1.87 (1.33-2.63)

1.62 (1.27-2.86)

  1. A P value of less than 0.013 (0.05/4) was considered statistically significant after Bonferroni correction. Haplotype GTC and GCT in block 2 remained significant after Bonferroni correction. aHaplotype frequencies of less than 5% were not included in the analyses; bthe order of polymorphisms was rs5744002, rs3793963, rs3793964, and rs3750920; cthe order of polymorphisms was rs5743944, rs5743942, and rs5743867. CI, confidence interval; LD, linkage disequilibrium; OR, odds ratio; ORadj, odds ratio adjusted for age and gender; Padj, P value adjusted for age and gender; TOLLIP, Toll-interacting protein.
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Critical Care

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