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Table 3 Association analysis of the eight single-nucleotide polymorphisms in TOLLIP between sepsis patients and healthy control subjects

From: Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population

   

Allelic comparison

Genotypic comparison

SNP

Control

Sepsis

P

P adj

OR (95% CI)

OR adj (95% CI)

P

P adj

rs3750920

        

   AA

29 (7.5%)

26(7.0%)

      

   AG

159 (41.3%)

160 (43.1%)

      

   GG

197 (51.2%)

185 (49.9%)

0.867

0.972

1.02 (0.82-1.27)

1.01 (0.72-1.38)

0.867

0.911

rs5743867

        

   CC

64 (16.6%)

32 (8.6%)

      

   CT

176 (45.7%)

161 (43.3%)

      

   TT

145 (37.7%)

179 (48.1%)

0.00016

0.00062

0.67 (0.54-0.82)

0.71 (0.59-0.86)

0.001

0.0018

rs3793964

        

   GG

39 (10.2%)

41 (11.1%)

      

   AG

196 (51.0%)

210 (56.6%)

      

   AA

149 (38.8%)

120 (32.3%)

0.140

0.251

1.17 (0.95-1.44)

1.09 (0.82-1.39)

0.179

0.280

rs3793963

        

   AA

18 (4.7%)

22 (5.9%)

      

   AG

151 (39.4%)

145 (39.1%)

      

   GG

214 (55.9%)

204 (55.0%)

0.635

0.664

1.06 (0.84-1.37)

1.04 (0.81-1.29)

0.752

0.794

rs5744002

        

   AA

42 (10.9%)

35 (9.5%)

      

   AG

161 (41.9%)

175 (47.4%)

      

   GG

181 (47.2%)

159 (43.1%)

0.591

0.694

1.06 (0.86-1.32)

1.02 (0.84-1.26)

0.752

0.810

rs5743942

        

   CC

6 (1.6%)

4 (1.1%)

      

   CT

65 (16.8%)

95 (25.5%)

      

   TT

315 (81.6%)

274 (73.4%)

0.021

0.034

1.45 (1.06-1.98)

1.40 (1.03-1.88)

0.013

0.016

rs5743944

        

   AA

19 (4.9%)

32 (8.7%)

      

   AG

156 (40.5%)

131 (35.4%)

      

   GG

210 (54.6%)

207 (55.9%)

0.607

0.642

1.06 (0.84-1.34)

1.03 (0.81-1.30)

0.074

0.102

rs5743947

        

   AA

33 (8.6%)

34 (9.2%)

      

   AG

157 (41.0%)

177 (47.8%)

      

   GG

193 (50.4%)

159 (43.0%)

0.094

0.302

1.21 (0.97-1.50)

1.05 (0.85-1.31)

0.118

0.231

  1. Data are presented as number (percentage) of subjects. P was determined using the chi-square test. P value adjusted for age and gender (Padj) came from multivariate logistic regression. A P value of less than 0.003 (0.05/16) was considered statistically significant after Bonferroni correction. Rs5743867 remained significant after Bonferroni correction. CI, confidence interval; OR, odds ratio; ORadj, odds ratio adjusted for age and gender; SNP, single-nucleotide polymorphism; TOLLIP, Toll-interacting protein.