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Table 1 Characteristics of the genotyped single-nucleotide polymorphisms in the genes of Toll-like receptor signaling pathways and negative regulators

From: Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population

Gene

Location

SNP

SNP type

Major/minor allele

MAF

HWE P value

TLR2

4q32

rs1898830

Tag SNP, intron

A/G

0.45

0.35

  

rs3804099

Tag SNP, exon

T/C

0.32

0.64

TLR4

9q32-q33

rs2149356

Tag SNP, intron

G/T

0.39

0.76

  

rs11536879

Tag SNP, intron

A/G

0.16

0.47

  

rs1927907

Tag SNP, intron

C/T

0.24

1.00

TLR9

3p21.3

rs352140

Tag SNP, exon

G/A

0.38

1.00

MyD88

3p22

rs7744

Tag SNP, 3' UTR

A/G

0.38

0.41

  

rs6853

Tag SNP, 3' UTR

A/G

0.01

1.00

TOLLIP

11p15.5

rs3750920

Tag SNP, exon

G/A

0.28

0.57

  

rs5743867

Tag SNP, intron

T/C

0.35

0.61

  

rs3793964

Tag SNP, intron

A/G

0.37

0.07

  

rs3793963

Intron

G/A

0.25

0.30

  

rs5744002

Intron

G/A

0.33

1.00

  

rs5743942

Tag SNP, intron

T/C

0.12

1.00

  

rs5743944

Intron

G/A

0.26

0.87

  

rs5743947

Intron

G/A

0.31

0.53

  1. HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency; MyD88, myeloid differentiation factor 88; SNP, single-nucleotide polymorphism; TLR, Toll-like receptor; TOLLIP, Toll-interacting protein; UTR, untranslated region.