Plasma soluble vascular endothelial growth factor receptor-1 levels predict outcomes of pneumonia-related septic shock patients: a prospective observational study

Table 2 Cox proportional hazards models for mortality prediction by comorbidities, biomarkers, and APACHE II score in patients with pneumonia-related septic shock

	Univariate Cox model		Multivariate Cox model
Variables	HR (95% CI)	P value	HR (95% CI)	P value
Age	1.00 (0.97-1.03)	0.92
Comorbidity
Diabetes mellitus	1.15 (0.61-2.18)	0.66
Obstructive airway disease	0.79 (0.38-1.63)	0.52
Interstitial lung disease	0.72 (0.29-1.83)	0.50
Chronic renal insufficiency	1.24 (0.60-2.58)	0.56
Congestive heart failure	0.74 (0.26-2.05)	0.56
sVEGFR1, quartile	1.97 (1.46-2.65)	<0.001	1.55 (1.05-2.30)	0.029
uPA, quartile	1.58 (1.19-2.10)	0.002	1.18 (0.77-1.79)	0.45
VEGF, quartile	1.09 (0.83-1.44)	0.52
APACHE II, quartile	2.44 (1.78-3.35)	<0.001	2.30 (1.53-3.49)	<0.001

Relative risk and 95% confidence interval (CI) were derived from the Cox proportional hazards regression model. APACHE II, Acute Physiology and Chronic Health Evaluation II; HR, hazard ratio; sVEGFR1, soluble vascular endothelial growth factor receptor 1; uPA, urokinase plasminogen activator; VEGF, vascular endothelial growth factor.

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