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Table 4 Structural and inflammatory data on small airways in ARDS patients and controls

From: Small airway remodeling in acute respiratory distress syndrome: a study in autopsy lung tissue

 

ARDS

Controls

P

Normal epithelium

32.9 ± 27.2

76.7 ± 32.7

< 0.001

Abnormal epithelium

14.4 ± 14.8

1.37 ± 3.20

0.007

Denudated epithelium

52.6 ± 35.2

21.8 ± 32.1

0.015

Airway wall thickness

138.7 ± 54.3

86.4 ± 33.3

0.005

Inner layer thickness

35.2 ± 32.0

17.2 ± 8.14

0.034

Smooth Muscle thickness

14.8 ± 8.20

18.5 ± 22.7

0.427

Outer layer thickness

88.7 ± 29.9

50.4 ± 17.7

< 0.001

Inflammation index [median(range)]

1(3)

0(1)

0.027

  1. ARDS, acute respiratory distress syndrome.
  2. Values are expressed as mean ± SD, unless otherwise specified. Epithelium parameters are expressed as a percentage of the airway basement membrane perimeter (%). Airway layers are presented as area (μm2) corrected by the basement membrane perimeter (μm).
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