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Table 3 Head-to-head comparison of CSF lactate concentration and other conventional markers

From: Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: a systemic review and meta-analysis

Study (ref)

Conventional markers (location)

Conventional markers assay results

Lactate assay results

  

TP

FP

FN

TN

DOR

TP

FP

FN

TN

DOR

Shaltouta,b,c[40]

Glucose (CSF)

10

1

6

41

68.3

14

1

2

41

287.0

Donalda,c[41]

 

33

2

15

67

73.7

45

3

3

69

345.0

Pönkä[47]

 

5

0

5

27

55.0

10

1

1

26

260.0

Briema,c[48]

 

30

0

23

193

502.3

47

4

0

167

3,536.1

Lannigan[53]

 

11

4

2

10

13.8

13

3

1

11

47.7

Gentona,b[39]

Glucose quotient (CSF/plasma)

21

0

2

27

473.0

24

0

1

28

931.0

Nelsonb[42]

 

10

0

7

26

74.2

18

3

0

25

269.6

Briema,c[48]

 

40

1

13

191

587.7

47

4

0

167

3,536.1

Berga[49]

 

16

10

2

78

62.4

16

9

2

112

99.6

Gentona,b[39]

Protein concentration (CSF)

18

0

3

25

269.6

24

0

1

28

931.0

Shaltouta,b,c[40]

 

13

0

3

42

327.9

14

1

2

41

287.0

Donalda,c[41]

 

39

1

9

68

294.7

45

3

3

69

345.0

Vanprapar[45]

 

8

0

3

12

60.7

12

0

1

18

308.3

Pönkä[47]

 

10

11

1

16

14.5

10

1

1

26

260.0

Briema,c[48]

 

41

7

9

184

119.8

47

4

0

167

3,536.1

Berga[49]

 

11

14

4

88

17.3

16

9

2

112

99.6

Gentona,b[39]

Leukocytes (CSF total number)

16

0

8

26

102.9

24

0

1

28

931.0

Shaltouta,b,c[40]

 

10

2

6

39

32.5

14

1

2

41

287.0

Nelsonb[42]

 

17

1

1

26

442.0

18

3

0

25

269.6

Pönkä[47]

 

7

2

4

25

21.9

10

1

1

26

260.0

Lannigan[53]

 

12

2

2

12

36.0

13

3

1

11

47.7

Gentona,b[39]

Granulocytes (CSF %)

20

7

4

19

13.6

24

0

1

28

931.0

Pönkä[47]

Neutrophils (CSF number)

7

6

4

21

6.1

10

1

1

26

260.0

  1. aIncluded TB meningitis;bincluded prior treated patients;c included normal patients in the AM group. TP, true-positive; FP, false-positive; FN, false-negative; TN, true-negative; DOR, diagnostic odds ratio.