Genome-wide transcription profiling of human sepsis: a systematic review

Table 4 Gene-expression changes in pathogen recognition

	Pathogen recognition	Signal transduction
Johnson[27, 28]	Increase expression in toll-like receptor (TLR) pathway genes.	Increased expression in pathways genes associated with NF-k B, STAT, JAK and MAPKs.
Talwar[8]	Increase expression in TLR pathway genes.	Increased expression in genes associated with STAT, JAK and MAPKs pathways.
Calvano[10]	Increase expression in TLR pathway genes and CD14 genes.	Increased expression in genes associated with STAT, NF-k B, CREB, JAK and MAPKs pathways.
Prabhakar[9]	Increase expression in genes encoding for CD14 molecules.	Increased expression in genes associated with JAK pathway.
Prucha[14]		Increased expression in genes associated with MAPKs pathway.
Tang-1[15, 16]		Reduced expression in pathways genes associated with NF-k B and MAPKs pathways.
Tang-2[18]	Increase expression in TLR pathways genes.	Increased expression in genes associated with JAK, STAT and MAPKs pathways.
Cobb[20, 21]		Increased expression in genes associated with MAPKs pathway.
Wong[23–26]	Increase expression in TLR pathways genes.	Increased expression in genes associated with NF-k B STAT and MAPKs pathways.
Payen[19]	Increase expression in TLR pathways genes in survivors.	Greater expression of genes associated with MAPKs pathway in non-survivors.
Pachot[22]	Increase expression in TLR pathways genes in survivors.	Greater expression of genes associated with MAPKs pathway in non-survivors.

Abbreviations; NF-ĸB denotes nuclear factor kappa-B, MAPKs denotes mitogen activated protein kinase, JAK denotes Janus Kinase, STAT denotes transducer and activator of transcription protein, CREB denotes cAMP responsive element binding protein, TLR denotes toll-like receptor.

ISSN: 1364-8535