Hydrogen inhalation ameliorates ventilator-induced lung injury

Table 1 Lung injury scores after 2 hours of ventilator-induced lung injury (30 mL/kg)

		Lung injury score
Group	Treatment	Alveolar congestion	Hemorrhage	Infiltration of neutrophils	Alveolar wall thickness	Total score
Sham	N₂	0.25 ± 0.50	0	0.50 ± 0.58	0	0.75 ± 0.50
Sham	H₂	0.25 ± 0.50	0	0.25 ± 0.50	0	0.50 ± 0.58
VILI	N₂	1.75 ± 0.50	0	1.75 ± 0.96	1.50 ± 0.58	5.0 ± 1.63*
VILI	H₂	0.75 ± 0.50	0	1.50 ± 0.57	0.75 ± 0.50	3.0 ± 0.82

Data are presented as mean ± standard deviation (* P < 0.05 versus ventilator-induced lung injury [VILI]/N₂). Acute lung injury was scored in each sample (n = 6 for each group) according to the following four items: alveolar congestion, hemorrhage, infiltration or aggregation of neutrophils in airspace or the vessel wall, and thickness of the alveolar wall/hyaline membrane formation. Each item was graded according to a 5-point scale: 0, minimal (little) damage; 1, mild damage; 2, moderate damage; 3, severe damage; and 4, maximal damage.

ISSN: 1364-8535