| |
Levosimendan (n = 20)
|
Control (n = 20)
|
P value
|
---|
CI, L/min per m2
|
BL
|
3.6 (2.9; 4.3)
|
3.9 (2.9; 4.6)
|
0.70
|
|
24 hours
|
4.1 (3.5; 5.1)a
|
4.1 (3.3; 5.0)
|
0.66
|
HR, beats per minute
|
BL
|
96 (87; 107)
|
95 (90; 106)
|
0.75
|
|
24 hours
|
94 (86; 104)
|
98 (87; 114)
|
0.36
|
MAP, mm Hg
|
BL
|
70 (67; 72)
|
72 (70; 74)
|
0.11
|
|
24 hours
|
72 (69; 73)
|
73 (70; 75)
|
0.13
|
PAOP, mm Hg
|
BL
|
18 (15; 18)
|
19 (15; 21)
|
0.25
|
|
24 hours
|
16 (16; 18)
|
17 (14; 21)
|
0.52
|
RAP, mm Hg
|
BL
|
14 (11; 16)
|
14 (11; 16)
|
0.81
|
|
24 hours
|
13 (11; 14)
|
14 (10; 18)
|
0.27
|
LVSWI, g·m/m2
|
BL
|
26 (21; 32)
|
30 (25; 36)
|
0.13
|
|
24 hours
|
34 (29; 38)a
|
32 (29; 38)
|
0.56
|
DO2I, mL/min per m2
|
BL
|
431 (363; 531)
|
492 (393; 550)
|
0.27
|
|
24 hours
|
512 (438; 612)
|
519 (436; 593)
|
0.93
|
VO2I, mL/min per m2
|
BL
|
111 (93; 151)
|
126 (112; 153)
|
0.18
|
|
24 hours
|
127 (107; 144)
|
149 (110; 178)
|
0.24
|
O2-ER, percentage
|
BL
|
28 (24; 32)
|
29 (22; 34)
|
0.99
|
|
24 hours
|
25 (20; 27)a
|
27 (21; 36)
|
0.17
|
SaO2, percentage
|
BL
|
98 (96; 99)
|
98 (95; 99)
|
0.99
|
|
24 hours
|
99 (99; 99)a
|
99 (94; 99)
|
0.02
|
PaCO2, mm Hg
|
BL
|
45 (41; 50)
|
41 (37; 51)
|
0.35
|
|
24 hours
|
41 (37; 44)
|
41 (36; 49)
|
0.42
|
SvO2, percentage
|
BL
|
72 (66; 75)
|
70 (66; 78)
|
0.95
|
|
24 hours
|
77 (74; 81)a
|
71 (62; 78)
|
0.06
|
Hba, g/dL
|
BL
|
8.6 (8.0; 8.9)
|
9.0 (8.0; 9.6)
|
0.96
|
|
24 hours
|
8.5 (8.0; 8.9)
|
8.8 (8.0; 9.3)
|
0.42
|
pHa, -log10c(H+)
|
BL
|
7.29 (7.25; 7.34)
|
7.28 (7.25; 7.38)
|
0.87
|
|
24 hours
|
7.38 (7.29; 7.40)a
|
7.32 (7.23; 7.37)
|
0.06
|
aBE, mmol/L
|
BL
|
-4.9 (-6.9; -2.5)
|
-3.8 (-9.0; 0.0)
|
0.72
|
|
24 hours
|
-2.9 (-5.0; -0.6)
|
-3.8 (-8.9; 1.8)
|
0.74
|
Lactate, mmol/L
|
BL
|
2.3 (1.3; 2.9)
|
1.9 (1.3; 2.9)
|
0.72
|
|
24 hours
|
1.9 (1.2; 2.5)
|
1.6 (1.3; 3.6)
|
0.61
|
Fluid input, mL/24 hours
|
BL
|
NA
|
NA
|
NA
|
|
24 hours
|
5,700 (4,700; 6,050)
|
4,850 (4,150; 5,200)
|
0.01
|
NE dosage, μg/kg per min
|
BL
|
0.4 (0.2; 0.9)
|
0.4 (0.3; 0.7)
|
0.72
|
|
24 hours
|
0.3 (0.1; 0.9)
|
0.4 (0.3; 1.1)
|
0.10
|
- Data are presented as median (25th; 75th percentile). Control, dobutamine 5 μg/kg per minute. aP < 0.05 versus baseline (BL) within groups. aBE, arterial base excess; CI, cardiac index; DO2I, systemic oxygen delivery index; Hba, arterial hemoglobin concentration; HR, heart rate; LVSWI, left ventricular stroke work index; MAP, mean arterial pressure; NA, not applicable; NE, norepinephrine; O2-ER, oxygen extraction ratio; PaCO2, arterial partial pressure of carbon dioxide; PAOP, pulmonary arterial occlusion pressure; pHa, arterial potentia hydrogenii; RAP, right atrial pressure; SaO2, arterial oxygen saturation; SvO2, mixed-venous oxygen saturation; VO2I, oxygen consumption index.