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Table 2 Hemodynamic and metabolic data of the study patients

From: Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study

   Levosimendan (n = 20) Control (n = 20) P value
CI, L/min per m2 BL 3.6 (2.9; 4.3) 3.9 (2.9; 4.6) 0.70
  24 hours 4.1 (3.5; 5.1)a 4.1 (3.3; 5.0) 0.66
HR, beats per minute BL 96 (87; 107) 95 (90; 106) 0.75
  24 hours 94 (86; 104) 98 (87; 114) 0.36
MAP, mm Hg BL 70 (67; 72) 72 (70; 74) 0.11
  24 hours 72 (69; 73) 73 (70; 75) 0.13
PAOP, mm Hg BL 18 (15; 18) 19 (15; 21) 0.25
  24 hours 16 (16; 18) 17 (14; 21) 0.52
RAP, mm Hg BL 14 (11; 16) 14 (11; 16) 0.81
  24 hours 13 (11; 14) 14 (10; 18) 0.27
LVSWI, g·m/m2 BL 26 (21; 32) 30 (25; 36) 0.13
  24 hours 34 (29; 38)a 32 (29; 38) 0.56
DO2I, mL/min per m2 BL 431 (363; 531) 492 (393; 550) 0.27
  24 hours 512 (438; 612) 519 (436; 593) 0.93
VO2I, mL/min per m2 BL 111 (93; 151) 126 (112; 153) 0.18
  24 hours 127 (107; 144) 149 (110; 178) 0.24
O2-ER, percentage BL 28 (24; 32) 29 (22; 34) 0.99
  24 hours 25 (20; 27)a 27 (21; 36) 0.17
SaO2, percentage BL 98 (96; 99) 98 (95; 99) 0.99
  24 hours 99 (99; 99)a 99 (94; 99) 0.02
PaCO2, mm Hg BL 45 (41; 50) 41 (37; 51) 0.35
  24 hours 41 (37; 44) 41 (36; 49) 0.42
SvO2, percentage BL 72 (66; 75) 70 (66; 78) 0.95
  24 hours 77 (74; 81)a 71 (62; 78) 0.06
Hba, g/dL BL 8.6 (8.0; 8.9) 9.0 (8.0; 9.6) 0.96
  24 hours 8.5 (8.0; 8.9) 8.8 (8.0; 9.3) 0.42
pHa, -log10c(H+) BL 7.29 (7.25; 7.34) 7.28 (7.25; 7.38) 0.87
  24 hours 7.38 (7.29; 7.40)a 7.32 (7.23; 7.37) 0.06
aBE, mmol/L BL -4.9 (-6.9; -2.5) -3.8 (-9.0; 0.0) 0.72
  24 hours -2.9 (-5.0; -0.6) -3.8 (-8.9; 1.8) 0.74
Lactate, mmol/L BL 2.3 (1.3; 2.9) 1.9 (1.3; 2.9) 0.72
  24 hours 1.9 (1.2; 2.5) 1.6 (1.3; 3.6) 0.61
Fluid input, mL/24 hours BL NA NA NA
  24 hours 5,700 (4,700; 6,050) 4,850 (4,150; 5,200) 0.01
NE dosage, μg/kg per min BL 0.4 (0.2; 0.9) 0.4 (0.3; 0.7) 0.72
  24 hours 0.3 (0.1; 0.9) 0.4 (0.3; 1.1) 0.10
  1. Data are presented as median (25th; 75th percentile). Control, dobutamine 5 μg/kg per minute. aP < 0.05 versus baseline (BL) within groups. aBE, arterial base excess; CI, cardiac index; DO2I, systemic oxygen delivery index; Hba, arterial hemoglobin concentration; HR, heart rate; LVSWI, left ventricular stroke work index; MAP, mean arterial pressure; NA, not applicable; NE, norepinephrine; O2-ER, oxygen extraction ratio; PaCO2, arterial partial pressure of carbon dioxide; PAOP, pulmonary arterial occlusion pressure; pHa, arterial potentia hydrogenii; RAP, right atrial pressure; SaO2, arterial oxygen saturation; SvO2, mixed-venous oxygen saturation; VO2I, oxygen consumption index.
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