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Table 3 Univariate and multivariable analyses of cortisol and cytokine concentrations in the two groups of patients

From: Relationship between alcohol use disorders, cortisol concentrations, and cytokine levels in patients with sepsis

 

Univariate analysis

Multivariable analysis**

 

AUD present

AUD absent

p

AUD present

AUD absent

P

Cortisol (microg/dl) *

39 (27.0; 60.0)

24 (18.7; 31.4)

0.04

44 (31.0; 62.9)

23 (8.0; 29.1)

0.004

IL10 (picog/ml) *

198 (63.1; 621.5)

47 (20.1; 110.7)

0.02

182 (51.0; 646.4)

23 (6.8; 80.0)

0.049

IL6 (picog/ml) *

527 (154.6; 1794.2)

156 (72.0; 339.2)

0.048

641 (169.1; 2426.5)

137 (40.4; 465.1)

0.10

TNFα (picog/ml) *

30 (18.3; 50.4)

24 (17.0; 34.8)

0.23

44 (25.9; 74.9)

25 (15.9; 40.4)

0.06

IL1β (picog/ml) *

2 (0.4; 14.9)

6 (1.5; 21.1)

0.41

8 (1.1; 56.5)

3 (0.7; 14.7)

0.82

IL6/IL10 *

3.0 (1.27; 6.93)

4.9 (2.80; 8.67)

0.17

3 (1.2; 8.0)

8 (3.3; 19.5)

0.32

TNFα/IL10 *

0.15 (0.005; 0.437)

0.52 (0.240; 1.139)

0.03

0.11 (0.041; 0.292)

0.63 (0.307; 1.293)

0.01

IL1β/IL10

0.01 (0.001; 0.052)

0.10 (0.020; 0.530)

0.04

0.01 (0.001; 0.029)

0.03 (0.07; 0.104)

0.04

  1. * mean, 95% confidence interval.
  2. ** Adjusted for age, glucose, cirrhosis, and vasopressor use.
  3. AUD, alcohol use disorders; IL, interleukin; TNF, tumor necrosis factor.