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Table 3 Univariate and multivariable analyses of cortisol and cytokine concentrations in the two groups of patients

From: Relationship between alcohol use disorders, cortisol concentrations, and cytokine levels in patients with sepsis

  Univariate analysis Multivariable analysis**
  AUD present AUD absent p AUD present AUD absent P
Cortisol (microg/dl) * 39 (27.0; 60.0) 24 (18.7; 31.4) 0.04 44 (31.0; 62.9) 23 (8.0; 29.1) 0.004
IL10 (picog/ml) * 198 (63.1; 621.5) 47 (20.1; 110.7) 0.02 182 (51.0; 646.4) 23 (6.8; 80.0) 0.049
IL6 (picog/ml) * 527 (154.6; 1794.2) 156 (72.0; 339.2) 0.048 641 (169.1; 2426.5) 137 (40.4; 465.1) 0.10
TNFα (picog/ml) * 30 (18.3; 50.4) 24 (17.0; 34.8) 0.23 44 (25.9; 74.9) 25 (15.9; 40.4) 0.06
IL1β (picog/ml) * 2 (0.4; 14.9) 6 (1.5; 21.1) 0.41 8 (1.1; 56.5) 3 (0.7; 14.7) 0.82
IL6/IL10 * 3.0 (1.27; 6.93) 4.9 (2.80; 8.67) 0.17 3 (1.2; 8.0) 8 (3.3; 19.5) 0.32
TNFα/IL10 * 0.15 (0.005; 0.437) 0.52 (0.240; 1.139) 0.03 0.11 (0.041; 0.292) 0.63 (0.307; 1.293) 0.01
IL1β/IL10 0.01 (0.001; 0.052) 0.10 (0.020; 0.530) 0.04 0.01 (0.001; 0.029) 0.03 (0.07; 0.104) 0.04
  1. * mean, 95% confidence interval.
  2. ** Adjusted for age, glucose, cirrhosis, and vasopressor use.
  3. AUD, alcohol use disorders; IL, interleukin; TNF, tumor necrosis factor.