From: Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study
Polymorphism/location (major/minor allele) | Status | Genotype distributiona | Total | Genotypic 3 × 2 chi-square (Pvalue) | Heterozygote protection modelb | |||
---|---|---|---|---|---|---|---|---|
 |  | AA | Aa | aa |  |  | OR (95% CI) | P valuec |
rs4925858, -3,771, 5' upstream (G/A) | Control | 255 (46.4%) | 247 (44.9%) | 48 (8.7%) | 550 | 4.104 (0.128) | 0.80 (0.64 to 1.00) | 0.053 |
 | Bacteraemia | 343 (49.9%) | 271 (39.4%) | 73 (10.6%) | 687 |  |  |  |
 | Gram-positive bacteraemia | 167 (49.9%) | 125 (37.3%) | 43 (12.8%) | 335 | 6.806 (0.034) | 0.73 (0.55 to 0.96) | 0.026 |
 | Pneumococcal bacteraemia | 83 (48.8%) | 62 (36.5%) | 25 (14.7%) | 170 | 6.900 (0.032) | 0.70 (0.49 to 1.00) | 0.052 |
rs760477, -263, intron 4 (C/T) | Control | 262 (53.0%) | 192 (38.9%) | 40 (8.1%) | 494 | 9.445 (0.009) | 0.68 (0.53 to 0.87) | 0.002 |
 | Bacteraemia | 403 (60.6%) | 201 (30.2%) | 61 (9.2%) | 665 |  |  |  |
 | Gram-positive bacteraemia | 197 (60.4%) | 97 (29.8%) | 32 (9.8%) | 326 | 7.205 (0.027) | 0.67 (0.49 to 0.90) | 0.007 |
 | Pneumococcal bacteraemia | 93 (56.4%) | 52 (31.5%) | 20 (12.1%) | 165 | 4.259 (0.119) | 0.72 (0.50 to 1.05) | 0.090 |