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Table 6 NFKBIL2 polymorphism genotype frequencies in Kenyan children with bacteraemia (overall, Gram-positive, and pneumococcal) and controls

From: Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study

Polymorphism/location (major/minor allele)

Status

Genotype distributiona

Total

Genotypic 3 × 2 chi-square (Pvalue)

Heterozygote protection modelb

  

AA

Aa

aa

  

OR (95% CI)

P valuec

rs4925858, -3,771, 5' upstream (G/A)

Control

255

(46.4%)

247

(44.9%)

48

(8.7%)

550

4.104 (0.128)

0.80 (0.64 to 1.00)

0.053

 

Bacteraemia

343

(49.9%)

271

(39.4%)

73

(10.6%)

687

   
 

Gram-positive bacteraemia

167

(49.9%)

125

(37.3%)

43

(12.8%)

335

6.806 (0.034)

0.73 (0.55 to 0.96)

0.026

 

Pneumococcal bacteraemia

83

(48.8%)

62

(36.5%)

25

(14.7%)

170

6.900 (0.032)

0.70 (0.49 to 1.00)

0.052

rs760477, -263, intron 4 (C/T)

Control

262

(53.0%)

192

(38.9%)

40

(8.1%)

494

9.445 (0.009)

0.68 (0.53 to 0.87)

0.002

 

Bacteraemia

403

(60.6%)

201

(30.2%)

61

(9.2%)

665

   
 

Gram-positive bacteraemia

197

(60.4%)

97

(29.8%)

32

(9.8%)

326

7.205 (0.027)

0.67 (0.49 to 0.90)

0.007

 

Pneumococcal bacteraemia

93

(56.4%)

52

(31.5%)

20

(12.1%)

165

4.259 (0.119)

0.72 (0.50 to 1.05)

0.090

  1. OR, odds ratio; CI, confidence interval. aNumber of individuals (%). bComparison of heterozygotes [Aa] with homozygotes [AA + aa]. c2 × 2 chi-squared comparison, one degree of freedom. P values below 0.05 are highlighted in bold.