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Table 5 NFKBIL2 and flanking gene polymorphism genotype frequencies in Kenyan individuals with bacteraemia and controls

From: Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study

Polymorphism/locationa (major/minor allele)

Status

Genotype distributionb

Genotypic 3 × 2 chi-square (Pvalue)

Heterozygote protection modelc

  

AA

Aa

aa

 

OR (95% CI)

P valued

rs10448143, -5,224, 5' upstream (C/T)

Control

433 (89.6%)

50 (10.4%)

0 (0%)

0.250e

0.78 (0.52 to 1.17)

0.226

 

Bacteraemia

598 (91.4%)

54 (8.3%)

2 (0.3%)

   

rs2170096, -4,368, 5' upstream (C/G)

Control

128 (38.7%)

136 (41.1%)

67 (20.2%)

0.145

0.93 (0.66 to 1.31)

0.672

 

Bacteraemia

107 (45.7%)

92 (39.3%)

35 (15.0%)

   

rs4925858, -3,771, 5' upstream (G/A)

Control

255 (46.4%)

247 (44.9%)

48 (8.7%)

0.128

0.80 (0.64 to 1.00)

0.053

 

Bacteraemia

343 (49.9%)

271 (39.4%)

73 (10.6%)

   

rs760477, -263, NFKBIL2 intron 4 (C/T)

Control

262 (53.0%)

192 (38.9%)

40 (8.1%)

0.009

0.68 (0.53 to 0.87)

0.002

 

Bacteraemia

403 (60.6%)

201 (30.2%)

61 (9.2%)

   

rs2306384, +2,754, Ser/Gly, NFKBIL2 exon 11 (A/G)

Control

238 (45.0%)

224 (42.3%)

67 (12.7%)

0.427

0.84 (0.65 to 1.09)

0.195

 

Bacteraemia

214 (47.9%)

171 (38.3%)

62 (13.8%)

   

rs4082353, +12,589, NFKBIL2 intron 25 (G/T)

Control

160 (47.6%)

132 (39.3%)

44 (13.1%)

0.857

1.05 (0.75 to 1.47)

0.785

 

Bacteraemia

109 (45.4%)

97 (40.4%)

34 (14.2%)

   

rs2272658, +16,899, VPS28 intron 4 (C/T)

Control

135 (40.9%)

145 (43.9%)

50 (15.2%)

0.927

0.96 (0.69 to 1.33)

0.791

 

Bacteraemia

113 (42.5%)

114 (42.9%)

39 (14.7%)

   

rs13258200, +36,964, CPSF1 intron 2 (A/C)

Control

212 (37.7%)

245 (43.6%)

105 (18.7%)

0.801

1.06 (0.85 to 1.33)

0.601

 

Bacteraemia

259 (37.5%)

311 (45.1%)

120 (17.4%)

   

rs4380978, +68,695, ADCK5 intron 1 (G/C)

Control

246 (45.6%)

231 (42.8%)

63 (11.6%)

0.648

0.90 (0.71 to 1.13)

0.352

 

Bacteraemia

329 (47.7%)

277 (40.1%)

84 (12.2%)

   
  1. VPS28, vacuolar protein sorting 28; CPSF1, cleavage and polyadenylation-specific factor 1; ADCK5, aarF domain-containing kinase 5; OR, odds ratio; CI, confidence interval; IPD, invasive pneumococcal disease. aSNP positions listed are relative to the start of translation (in exon 5). bNumber of individuals (%). cComparison of heterozygotes [Aa] with homozygotes [AA + aa]. d2 × 2 chi-squared comparison, one degree of freedom. eFisher's exact test (two-tailed). P values below 0.05 are highlighted in bold.
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