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Table 1 Comparison of patients with metformin-associated lactic acidosis with patients with lactic acidosis of other origin

From: Outcome of severe lactic acidosis associated with metformin accumulation

  All patients (n= 197) MALA (n= 10) LAOO (n= 187) Post-cardiac arrest (n= 72) Septic shock (n= 42) Cardiogenic shock (n= 39) Mesenteric ischemia (n= 8) Hemorrhagic shock (n= 13) Other causes (n= 13)
Age, years 67 ± 13 66 ± 9 67 ± 13 65 ± 13 68 ± 12 73 ± 11 72 ± 9 64 ± 15 56 ± 14
Male gender 121 (61%) 4 (40%) 117 (63%) 45 (62%) 24 (57%) 26 (67%) 6 (75%) 7 (54%) 9 (69%)
SAPS II 74 ± 20 88 ± 23 73 ± 19a 81 ± 16 71 ± 19a 75 ± 18 73 ± 25 54 ± 15b 54 ± 14b
SOFA score 12.5 ± 3.6 14.3 ± 1.4 12.4 ± 3.7 12.9 ± 2.9 12.1 ± 4.5 11.8 ± 2.8b 14.4 ± 4.4 13.4 ± 4.6 9.6 ± 4.2b
   Respiratory 2.5 ± 1.0 2.7 ± 0.9 2.5 ± 1.0 2.7 ± 0.9 2.1 ± 1.3 2.4 ± 0.6 2.6 ± 1.1 2.3 ± 1.5 2.2 ± 1.4
   Renal 2.4 ± 1.2 4.0 ± 0.0 2.3 ± 1.2b 2.1 ± 1.2b 2.5 ± 1.2b 2.5 ± 1.1b 2.8 ± 0.8a 2.1 ± 1.5b 1.9 ± 1.3b
   Hepatic 0.7 ± 1.0 0.3 ± 0.7 0.7 ± 1.0 0.3 ± 0.6 1.3 ± 1.2a 0.6 ± 0.8 0.6 ± 0.9 1.8 ± 1.7 0.9 ± 0.9
   Cardiovascular 3.3 ± 1.4 4.0 ± 0.0 3.3 ± 1.5 3.5 ± 1.3 3.2 ± 1.5 3.4 ± 1.5 4.0 ± 0.0 2.9 ± 1.8 2.1 ± 2.0a
   Hematologic 0.9 ± 1.2 0.5 ± 0.8 0.9 ± 1.2 0.6 ± 0.9 1.3 ± 1.4 0.3 ± 0.7 2.2 ± 1.6 2.6 ± 1.1 0.9 ± 1.2
   Neurologic 2.7 ± 1.4 2.8 ± 1.5 2.7 ± 1.4 3.7 ± 0.6a 1.7 ± 1.3a 2.8 ± 1.2 2.2 ± 1.3 1.8 ± 1.4b 1.6 ± 1.2
Lactate, mmol/L 11.6 ± 6.2 18.7 ± 5.3 11.2 ± 6.1b 12.8 ± 6.1b 8.7 ± 4.5b 10.9 ± 5.2b 8.6 ± 3.3b 13.5 ± 9.5b 10.8 ± 7.1b
pH 7.13 ± 0.19 6.75 ± 0.13 7.15 ± 0.17b 7.07 ± 0.19b 7.23 ± 0.09b 7.18 ± 0.14b 7.27 ± 0.04b 7.26 ± 0.07b 7.14 ± 0.18b
Bicarbonate, mmol/L 14.6 ± 5.9 4.4 ± 2.4 15.2 ± 5.6b 14.5 ± 5.6b 16.6 ± 5.8b 14.9 ± 4.0b 16.2 ± 1.8b 15.8 ± 5.7b 14.1 ± 8.8b
Creatinine, μmol/L 307 ± 265 796 ± 324 227 ± 141b 169 ± 128b 318 ± 181b 182 ± 48b 299 ± 125a 303 ± 122a 214 ± 57b
Survival 52 (26%) 5 (50%) 48 (26%) 19 (26%) 9 (21%) 9 (23%) 0 5 (38%) 6 (46%)
  1. Values are presented as mean ± standard deviation or as number (percentage). Comparison with metformin-associated lactic acidosis (MALA): aP < 0.05, bP < 0.01. Simplified Acute Physiology Score II (SAPS II) and Sequential Organ Failure Assessment (SOFA) score were measured on admission. Other causes of lactic acidosis were respiratory exhaustion (3), alcoholic lactic acidosis (3), acute liver failure (2), status epilepticus (2), anaphylactic shock, hypovolemic shock, and disseminated intravascular coagulation in acute myeloid leukemia. LAOO, lactic acidosis of other origin.