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Table 3 Microbiologic characteristics of infectious episodes. Comparison between groups D and ND

From: De-escalation as part of a global strategy of empiric antibiotherapy management. A retrospective study in a medico-surgical intensive care unit

  Group D
n= 60
Group ND
n= 73
P-value
Microbiological samples, n (%) 59 (98) 63 (86) 0.17
Positive microbiological documentation, n (%) 40 (66.6) 39 (53.4) 0.23
Inadequate empiric antibiotherapy, n (%) § 3 (7.7%) 11 (27.5%) 0.02
Bacteria related to infection, n (%):    
   Staphylococcus aureus 11 (18.3) * 7 (9.6) * 0.18
   CoNS 5 (8.3) $ 0 0.02
   Streptococci species 3 (5) 8 (11) 0.47
   Enterococci species 2 (3.3) 2 (2.7) 0.89
   Gram negative cocci 2 (3.3) 0 0.14
   Enterobacteria 16 (26.6) 23 (31.5) 0.54
   nfGNB 4 (6.6) 5 (6.8) 0.9
   Others gram negative bacilli 7 (11.6) 5 (6.8) 0.14
   Intracellular bacteria 0 1 (1.3) 0.34
MDR responsible for the infection, n (%) 6 (10) 7 (9.6) 0.97
Polymicrobial infections, n (%) 13 (21.6) 13 (17.8) 0.81
Infection recurrence, n (%) 3 (5) 14 (19) 0.01
MDR during the ICU stay, n (%) 6 (10) 14 (19.1) 0.1
  1. § Among documented infection; *1 methicillin resistant; $ 2 methicillin resistant.
  2. CoNS, coagulase negative staphylococcus; MDR, multidrug resistant pathogen; nfGNB, non fermenting Gram-negative bacilli