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Table 3 Microbiologic characteristics of infectious episodes. Comparison between groups D and ND

From: De-escalation as part of a global strategy of empiric antibiotherapy management. A retrospective study in a medico-surgical intensive care unit

 

Group D

n= 60

Group ND

n= 73

P-value

Microbiological samples, n (%)

59 (98)

63 (86)

0.17

Positive microbiological documentation, n (%)

40 (66.6)

39 (53.4)

0.23

Inadequate empiric antibiotherapy, n (%) §

3 (7.7%)

11 (27.5%)

0.02

Bacteria related to infection, n (%):

   

   Staphylococcus aureus

11 (18.3) *

7 (9.6) *

0.18

   CoNS

5 (8.3) $

0

0.02

   Streptococci species

3 (5)

8 (11)

0.47

   Enterococci species

2 (3.3)

2 (2.7)

0.89

   Gram negative cocci

2 (3.3)

0

0.14

   Enterobacteria

16 (26.6)

23 (31.5)

0.54

   nfGNB

4 (6.6)

5 (6.8)

0.9

   Others gram negative bacilli

7 (11.6)

5 (6.8)

0.14

   Intracellular bacteria

0

1 (1.3)

0.34

MDR responsible for the infection, n (%)

6 (10)

7 (9.6)

0.97

Polymicrobial infections, n (%)

13 (21.6)

13 (17.8)

0.81

Infection recurrence, n (%)

3 (5)

14 (19)

0.01

MDR during the ICU stay, n (%)

6 (10)

14 (19.1)

0.1

  1. § Among documented infection; *1 methicillin resistant; $ 2 methicillin resistant.
  2. CoNS, coagulase negative staphylococcus; MDR, multidrug resistant pathogen; nfGNB, non fermenting Gram-negative bacilli