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Figure 6 | Critical Care

Figure 6

From: PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction

Figure 6

Levels of plasma cytokines and bacterial clearance. Mice underwent a sham procedure, CLP, CLP plus anti-PD-L1 administration, or CLP plus isotype control administration (n = 5 for each group). Levels of TNF-α (A), IL-6 (B) and IL-10 (C) were measured 24 h after surgery. Treatment with anti-PDL1 antibody improves bacterial clearance in septic mice. Mice that received anti-PD-L1 antibody exhibited a deceased bacterial burden in peritoneal lavage fluid in comparison with mice that received isotype antibody or saline (D), Mice that received anti-PD-L1 antibody exhibited a deceased bacterial burden in blood in comparison with mice that received isotype antibody or saline (E), * P < 0.05, ** P < 0.01.

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Critical Care

ISSN: 1364-8535