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Table 2 Regional microvascular blood flow

From: Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock

Parameter

Group

BL = 0 hours

6 hours

12 hours

24 hours

Cardiac index (l/min/m2)

Sham

100 ± 0

90.7 ± 2.8

86.2 ± 3.0

82.5 ± 3.0

 

Control

100 ± 0

117.1 ± 10.0

122.7 ± 5.9#†

166.2 ± 16.2#†

 

rhAPC

100 ± 0

109.6 ± 9.2

113.2 ± 6.6*†

124.2 ± 6.9*†

Pancreas (%)

Sham

100 ± 0

97.3 ± 10.5

94.9 ± 8.1

104.0 ± 16.1

 

Control

100 ± 0

55.5 ± 9.3

60.5 ± 12.3#

52.3 ± 6.9#†

 

rhAPC

100 ± 0

76.5 ± 9.5

61.3 ± 9.5#

65.5 ± 15.2#

Ileum (%)

Sham

100 ± 0

95.4 ± 20.2

89.1 ± 11.3

111.8 ± 23.5

 

Control

100 ± 0

102.4 ± 13.5

156.0 ± 38.6#†

135.1 ± 28.1

 

rhAPC

100 ± 0

95.6 ± 9.2

107.8 ± 19.0

136.0 ± 32.3

Medulla oblongata (%)

Sham

100 ± 0

91.3 ± 11.2

95.5 ± 8.3

93.1 ± 17.1

 

Control

100 ± 0

78.1 ± 7.1

132.1 ± 17.5

145.0 ± 16.7#

 

rhAPC

100 ± 0

75.3 ± 9.3

89.6 ± 22.4

97.2 ± 16.9

Thalamus (%)

Sham

100 ± 0

92.6 ± 7.4

95.2 ± 9.9

93.9 ± 13.8

 

Control

100 ± 0

90.2 ± 9.3

137.0 ± 18.1#

157.7 ± 31.6#

 

rhAPC

100 ± 0

96.1 ± 4.8

95.8 ± 9.1*

107.5 ± 10.3*

Pons (%)

Sham

100 ± 0

95.9 ± 9.9

92.6 ± 7.5

96.1 ± 18.3

 

Control

100 ± 0

87.7 ± 8.8

130.0 ± 14.7#

167.3 ± 26.7#†

 

rhAPC

100 ± 0

78.1 ± 6.0

81.8 ± 9.1*

104.4 ± 15.5*

  1. Regional microvascular blood flow (percentage from baseline). rhAPC, recombinant human activated protein C. P ≤0.05: #vs. BL, *vs. control, †vs. sham.