Skip to main content
Figure 1 | Critical Care

Figure 1

From: Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis

Figure 1

Mitochondrial respiration of intact platelets suspended in their own plasma or PBS glucose. A. Maximal respiration induced by titration of the protonophore FCCP demonstrated a significant increase in both media, from Day 1 to 2 to Day 6 to 7 as well as compared to controls. B. State 4 respiration in presence of the ATP synthase inhibitor oligomycin was significantly higher on Day 3 to 4 and Day 6 to 7 in platelets suspended in plasma compared to controls, whereas no difference was seen in PBS glucose. C. The control ratio (maximal respiration/state 4 respiration) in platelets incubated in patients' own plasma was significantly lower at Day 3 to 4 compared to controls. Mean values ± SEM (A, B) and median with interquartile range and range (C), n = 17 to 18, *P < 0.05.

Back to article page

Critical Care

ISSN: 1364-8535