Skip to main content

Table 1 Clinical patients' characteristics

From: Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma

Parameters

Overall population

n= 105

Septic

n= 37 (35%)

Non-septic

n= 68 (65%)

P value

Age, years

38.1 ± 16.9

34.8 ± 15.6

39.9 ± 17.5

0.15a

Male, % (n)

72.4% (n = 76)

78.4% (n = 29)

69.1% (n = 47)

0.43b

ISS

37.1 ± 9.9

38.7 ± 8.9

36.2 ± 10.4

0.20a

Severe brain injury, % (n)

41% (n = 43)

59% (n = 22)

31% (n = 21)

0.008b

Severe thoracic injury, % (n)

72% (n = 76)

65% (n = 24)

76% (n = 52)

0.30b

SAPS II

36.9 ± 15.6

43 ± 15.4

33.5 ± 14.8

0.003a

Delay for MAP >65 mm Hg, minutes

0 (0 to 0.25)

0 (0 to 16.25)

0 (0 to 0)

0.14c

Need for vasoactive support in emergency room, % (n)

24% (n = 25)

35% (n = 13)

18% (n = 12)

0.077b

Prophylactic antibiotics administrated in emergency room, % (n)

42% (n = 44)

35% (n = 13)

46% (n = 31)

0.41b

SOFA score

    

   D1

4 (2 to 7)

6 (4 to 9.2)

3 (2 to 5)

0.0001c

   D2

4 (2 to 6)

6 (3.75 to 9.25)

2.5 (1 to 5)

<0.0001c

   D3

3 (1 to 5)

7 (3 to 9.25)

2 (1 to 3)

<0.0001c

   D4

2 (1 to 5)

5 (2 to 8)

2 (1 to 3)

<0.0001c

   D5

2 (1 to 4)

4 (1.75 to 7.25)

1 (1 to 2)

<0.0001c

   D6

1 (1 to 3)

3 (1 to 7)

1 (1 to 2)

<0.0001c

mHLA-DR levels, antibodies per cell

   D1 and 2

11,371 ± 4,870

11,753 ± 4,291

11,177 ± 5,169

0.62a

   D3 and 4

12,224 ± 7,501

9,271 ± 6,029

13,723 ± 7,766

0.004a

   D5 and 6

15,623 ± 9,123

11,707 ± 6,004

16,602 ± 9535

0.05a

Variations in mHLA-DR, antibodies per cell

   D3 and 4/D1 and 2

1.25 ± 0.57

0.83 ± 0.43

1.44 ± 0.53

<0.0001a

   D5 and 6/D3 and 4

1.37 ± 1.11

1.32 ± 0.82

1.38 ± 1.18

0.83a

Deaths at day 28, % (n)

6% (n = 6)

8% (n = 3)

4% (n = 3)

0.73b

Mechanical ventilation, % (n)

66% (n = 69)

89% (n = 33)

53% (n = 36)

0.0004b

Duration of mechanical ventilation, days

6 (3 to 11)

9 (6.75 to 19)

3 (2 to 5.5)

<0.0001c

Massive transfusion required, % (n)

29% (n = 31)

35% (n = 13)

26% (n = 18)

0.48b

Volume of transfusion, mL

900 (0 to 2,850)

1,200 (0 to 3,500)

0 (0 to 2,700)

0.067c

Shock (need for vasoactive drug on D1 and 2), % (n)

33% (n = 35)

57% (n = 21)

21% (n = 14)

0.0004b

Length of stay in ICU, days

9 (6 to 15)

15 (10 to 24.25)

7 (5 to 11)

<0.0001c

  1. Parametric variables are expressed as mean ± standard deviation, and non-parametric variables are expressed as median (interquartile range) or frequencies. aIndependent samples t test; bchi-square test; cMann-Whitney test. D, days; ICU, intensive care unit; ISS, Injury Severity Score; MAP, mean arterial pressure; mHLA-DR, monocyte human leukocyte antigen-DR; SAPS II, Simple Acute Physiology Score II; SOFA, Sepsis-related Organ Failure Assessment.
Back to article page

Critical Care

ISSN: 1364-8535