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Table 3 Predictive value of different models predicting bacteremia in 581 adults with febrile UTI.

From: Procalcitonin reflects bacteremia and bacterial load in urosepsis syndrome: a prospective observational study

  

No. patients without risk factor (%)

Sensitivity, %

(95% CI)

Specificity, %

(95% CI)

NPV, %

(95% CI)

PPV, %

(95% CI)

LR +

(95% CI)

LR -

(95% CI)

Model 1

        

   Risk factor

A

271 (47)

70 (62 to 78)

52 (46 to 56)

86 (81 to 89)

30 (25 to 35)

1.45 (1.25 to 1.68)

0.58 (0.44 to 0.75)

   Risk factors

A, B

127 (22)

90 (83 to 94)

25 (21 to 30)

90 (83 to 94)

26 (22 to 30)

1.21 (1.12 to 1.30)

0.39 (0.23 to 0.66)

   Risk factors

A, B, C

112 (19)

93 (87 to 97)

23 (19 to 27)

92 (85 to 96)

26 (22 to 30)

1.21 (1.13 to 1.29)

0.30 (0.16 to 0.57)

Model 2

        

   Risk factor

B

270 (46)

68 (60 to 76)

51 (46 to 56)

85 (80 to 89)

29 (24 to 34)

1.39 (1.21 to 1.62)

0.61 (0.48 to 0.80)

   Risk factors

B, D

229 (39)

78 (70 to 85)

45 (40 to 49)

88 (83 to 92)

29 (25 to 34)

1.42 (1.26 to 1.61)

0.48 (0.34 to 0.67)

   Risk factors

P, B

140 (24)

97 (92 to 99)

30 (26 to 34)

97 (92 to 99)

29 (25 to 33)

1.39 (1.30 to 1.49)

0.10 (0.04 to 0.27)

   Risk factors

P, B, D

116 (20)

97 (92 to 99)

25 (21 to 29)

97 (91 to 99)

27 (23 to 32)

1.29 (1.21 to 1.37)

0.12 (0.05 to 0.33)

Model 3

        

   PCT > 0.25 µg/l

 

234 (40)

95 (89 to 98)

50 (46 to 55)

97 (94 to 99)

36 (31 to 41)

1.91 (1.73 to 2.11)

0.11 (0.05 to 0.22)

  1. NPV, negative predictive value; PPV, positive predictive value; LR+, positive likelihood ration; LR-, negative likelihood ratio; A, Age >65 years; B, Temperature >38.6°C; C, heart rate >100/minute; D, diabetes mellitus; P, PCT > 0.25 μg/l. For Model 1 and Model 2 the corresponding sensitivity, specificity, NPV, PPV, LR+ and LR- are calculated using a cutoff value of ≥1 risk factor.