Table 1 Patient data for all study patients and different types of infections
All patients | Community-acquired | Nosocomial | P value | |
|---|---|---|---|---|
Number of patients | 242 | 157/242 (64.9%) | 85/242 (35.1%) | < 0.001 |
Age in years (SD) | 59.8 (15.4) | 58.2 (15.6) | 62.7 (14.7) | 0.03 |
Males (percentage) | 165 (68.2%) | 109 (69.4%) | 56 (65.9%) | 0.57 |
APACHE II score (SD) | 24.0 (9.0) | 23.9 (8.8) | 24.1 (9.5) | 0.93 |
SAPS II (SD) | 43.8 (16.8) | 42.6 (16.0) | 46.1 (17.9) | 0.22 |
SOFA on day 1a (SD) | 8.4 (3.6) | 8.5 (3.6) | 8.2 (3.5) | 0.74 |
SOFAmaxb (SD) | 10.9 (4.3) | 11.0 (4.4) | 10.7 (4.1) | 0.68 |
Postoperative (percentage) | 63 (26.0%) | 31 (19.7%) | 32 (37.6%) | < 0.01 |
Chronic renal failure | 4 (1.7%) | 1 (0.6%) | 3 (3.5%) | 0.16 |
Chronic lung disease | 25 (10.3%) | 17 (10.8%) | 8 (9.4%) | 0.84 |
Chronic hepatic disease | 13 (5.4%) | 6 (3.8%) | 7 (8.2%) | 0.22 |
Immunosuppression | 30 (12.4%) | 20 (12.7%) | 10 (11.7%) | 0.80 |
ICU mortality | 33/242 (13.6%) | 20/157 (12.7%) | 13/85 (15.3%) | 0.58 |
Hospital mortality | 62/242 (25.6%) | 38/157 (24.2%) | 24/85 (28.2%) | 0.49 |
Source of infection | ||||
Pulmonary | 101 (41.7%) | 69 (43.9%) | 32 (37.6%) | 0.34 |
Intra-abdominal | 77 (31.9%) | 42 (26.8%) | 35 (41.2%) | 0.02 |
Skin or soft tissue | 24 (9.9%) | 17 (10.8%) | 7 (8.2%) | 0.52 |
Urinary tract | 11 (4.5%) | 8 (5.1%) | 3 (3.5%) | 0.58 |
Other | 33 (13.6%) | 24 (15.3%) | 9 (10.6%) | 0.31 |
Blood cultures | ||||
Blood cultures taken | 160/242 (66.1%) | 110/157 (70.1%) | 49/85 (57.6%) | |
Positive blood cultures | 69/160 (43.1%) | 56/110 (50.9%) | 13/49 (26.5%) | |
Microbes in positive blood cultures | ||||
Streptococcus pneumoniae | 13 | 13 | 0 | |
Staphylococcus aureus | 11 | 10 | 1 | |
Streptococcus species | 9 | 9 | 0 | |
Other Gram-positive | 4 | 4 | 0 | |
Escherichia coli | 14 | 11 | 3 | |
Other Gram-negative | 13 | 8 | 5 | |
Yeasts | 4 | 1 | 3 | |
Mycobacterium | 1 | 0 | 1 | |
Ongoing antibiotic treatment before day 0 | 98/242 (40.5%) | 38 (24.2%) | 60 (70.6%) | < 0.001 |