Nitroglycerin can facilitate weaning of difficult-to-wean chronic obstructive pulmonary disease patients: a prospective interventional non-randomized study

Table 2 Hemodynamics during weaning trials without (Control day) and with (Study day) nitroglycerin

Variable		Mechanical ventilation	Spontaneous breathing trial		P value^a
			Start	End
HR, beats/minute	Control day	91 ± 14	105 ± 14^b	111 ± 15^b	0.26
	Study day	94 ± 16	105 ± 16^b	107 ± 13^b
sBP, mm Hg	Control day	149 ± 19	179 ± 26^c	177 ± 25^c	0.002
	Study day	144 ± 21	142 ± 23^d	135 ± 15^d
mBP, mm Hg	Control day	94 ± 14	110 ± 21^b	109 ± 20^c	< 0.001
	Study day	91 ± 14	89 ± 15^d	85 ± 12^d
RPP, mm Hg beats/minute	Control day	13,708 ± 3,166	19,041 ± 4,129^b	19,856 ± 4,877^b	< 0.001
	Study day	13,400 ± 2,637	14,738 ± 2,706^d	14,625 ± 2,383^d
P_RA, mm Hg	Control day	11.7 ± 3.2	13 ± 5.6	13.3 ± 5.8	0.001
	Study day	10.6 ± 2.9	8.3 ± 3.5^d	8.7 ± 3.2^d
Mpap, mm Hg	Control day	29.9 ± 4.8	40.3 ± 6.2^b	41.6 ± 5.8^b	< 0.001
	Study day	28.8 ± 5.9	28.3 ± 4.6^d	28.3 ± 3.9^d
Ppao, mm Hg	Control day	14.8 ± 3.8	23.3 ± 7.6^b	23.4 ± 7.4^b	< 0.001
	Study day	14.8 ± 4.9	14.2 ± 3.7^d	14.8 ± 3.7^d
CO, L/minute	Control day	6.6 ± 2	8.2 ± 2	8.7 ± 2.5^c	0.89
	Study day	6.4 ± 2	8.3 ± 2.3^c	8.7 ± 2.7^b
SV, mL	Control day	73.2 ± 22.7	77.8 ± 16.3	78.8 ± 19.5	0.69
	Study day	70.3 ± 27.7	80.8 ± 26.8	81.3 ± 24.4
SVR, dyne/s per cm⁵	Control day	1,084 ± 387	992 ± 300	931 ± 277	0.10
	Study day	1,085 ± 361	827 ± 268^c	756 ± 252^b
PVR, dyne/s per cm⁵	Control day	199 ± 69	176 ± 70	171 ± 51	0.28
	Study day	192 ± 87	147 ± 57	137 ± 57^c
LVSW, g-m	Control day	78.2 ± 26.4	91.9 ± 31.2	93.4 ± 37.1	0.62
	Study day	73.5 ± 33.8	82.9 ± 35.6	78.3 ± 33.1
RVSW, g-m	Control day	18.5 ± 9	28.8 ± 8.2^b	30.8 ± 11.2^b	0.07
	Study day	17.6 ± 10.3	22.8 ± 12.1	22.3 ± 10.1^d

Values are presented as mean ± standard deviation. ^aP value of the interaction (day × time) of the repeated-measures two-way analysis of variance comparison between the Control day and Study day across time (that is, during mechanical ventilation and the 10th minute [Start] and last minute [End] of the spontaneous breathing trial). ^bP < 0.01 versus mechanical ventilation. ^cP< 0.05 versus mechanical ventilation. ^dP < 0.05 versus control day. CO, cardiac output; HR, heart rate; LVSW, left ventricular stroke work; mBP mean arterial blood pressure; mPAP mean pulmonary arterial pressure; Ppao, pulmonary artery occlusion pressure; P_RA, right atrial pressure; PVR, pulmonary vascular resistance; RPP, rate-pressure product; RVSW, right ventricular stroke work; sBP, systolic arterial blood pressure; SV, stroke volume; SVR systemic vascular resistance.

ISSN: 1364-8535