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Figure 3 | Critical Care

Figure 3

From: Mechanisms of leukocyte distribution during sepsis: an experimental study on the interdependence of cell activation, shear stress and endothelial injury

Figure 3

Interdependent effects of shear stress and cell activation on PMN adhesion. Adhesion of neutrophils under different activation protocols (mean ± SEM; n = 4), (a) non-activated controls, (b) activation with 100 ng/ml LPS and (c) activation with 10 ng/ml LPS. Blank symbols indicate activated PMN, filled symbols indicate non-activated PMN. (d-f) show the corresponding curves for predicted adhesion determined by ANCOVA of logarithms (continuous line: non-activated PMN, discontinuous line: activated PMN). Under all conditions of activation decreasing shear stress increased adhesion (P < 0.01; ANCOVA). On maximal activated endothelium activation of PMN decreased adhesion in comparison to non-activated PMN ((b and e), P < 0.01, ANCOVA). On sub-maximal activated endothelium (c and f), activation of PMN also decreased adhesion in comparison to non-activated controls, especially under conditions of low shear stress (P < 0.01, ANCOVA).

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Critical Care

ISSN: 1364-8535