Table 2 Variables determining respiration, oxygenation and ventilation in vehicle controls and netrin-1-treated animals

PaO₂/FiO₂ (mmHg)

Control

483 ± 31

513 ± 48

493 ± 77

LPS + Vehicle

453 ± 10

255 ± 38*

158 ± 30*

LPS + Netrin i.v.

491 ± 31

254 ± 18*

204 ± 31*

LPS + Netrin inh

487 ± 6

272 ± 11*

217 ± 20*

PaCO₂ (kPa)

Control

5.2 ± 0.2

5.1 ± 0.2

4.8 ± 0.1

LPS + Vehicle

5.0 ± 0.1

5.1 ± 0.2

5.4 ± 0.3

LPS + Netrin i.v.

5.3 ± 0.4

5.1 ± 0.2

5.2 ± 0.7

LPS + Netrin inh.

5.0 ± 0.2

4.6 ± 0.1

5.2 ± 0.3

DO₂ (ml min^-1 kg^-1)

Control

1207 ± 60

1139 ± 49

940 ± 88

LPS + Vehicle

1132 ± 61

1132 ± 97

1009 ± 28

LPS + Netrin i.v.

1207 ± 83

1139 ± 97

960 ± 69

LPS + Netrin inh

1102 ± 38

1147 ± 120

997 ± 84

P_peak (mbar)

Control

14.4 ± 0.4

14.5 ± 0.4

14.7 ± 0.8

LPS + Vehicle

14.4 ± 0.5

20.8 ± 2.1*

22.7 ± 3.0*

LPS + Netrin i.v.

14.4 ± 1.0

18.9 ± 1.4*

19.8 ± 1.8*

LPS + Netrin inh

14.2 ± 0.4

19.2 ± 0.2*

20.7 ± 0.7*

P_mean (mbar)

Control

8.1 ± 0.5

8.2 ± 0.5

8.4 ± 0.7

LPS + Vehicle

7.7 ± 0.2

10.3 ± 1.2

11.5 ± 1.8

LPS + Netrin i.v.

7.4 ± 0.2

9.3 ± 0.3

9.3 ± 0.3

LPS + Netrin inh.

7.6 ± 0.2

9.3 ± 0.1

10.1 ± 0.3

Compl.st. (ml cm H₂O^-1)

Control

28.3 ± 1.2

29.4 ± 1.0

29.5 ± 1.2

LPS + Vehicle

28.6 ± 0.7

19.3 ± 1.6*

18.2 ± 1.7*

LPS + Netrin i.v.

28.4 ± 2.0

19.9 ± 1.4*

19.3 ± 1.7*

LPS + Netrin inh

27.7 ± 1.4

19.1 ± 0.7*

17.7 ± 0.7*