TY - JOUR AU - Martin, G. S. AU - Mannino, D. M. AU - Eaton, S. AU - Moss, M. PY - 2003 DA - 2003// TI - The epidemiology of sepsis in the United States from 1979 through 2000 JO - N Engl J Med VL - 348 UR - https://doi.org/10.1056/NEJMoa022139 DO - 10.1056/NEJMoa022139 ID - Martin2003 ER - TY - JOUR AU - Byl, B. AU - Clevenbergh, P. AU - Jacobs, F. AU - Struelens, M. J. AU - Zech, F. AU - Kentos, A. AU - Thys, J. P. PY - 1999 DA - 1999// TI - Impact of infectious diseases specialists and microbiological data on the appropriateness of antimicrobial therapy for bacteremia JO - Clin Infect Dis VL - 29 UR - https://doi.org/10.1086/520182 DO - 10.1086/520182 ID - Byl1999 ER - TY - JOUR AU - Ibrahim, E. H. AU - Sherman, G. AU - Ward, S. AU - Fraser, V. J. AU - Kollef, M. H. PY - 2000 DA - 2000// TI - The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting JO - Chest VL - 118 UR - https://doi.org/10.1378/chest.118.1.146 DO - 10.1378/chest.118.1.146 ID - Ibrahim2000 ER - TY - JOUR AU - Kollef, M. H. AU - Sherman, G. AU - Ward, S. AU - Fraser, V. J. PY - 1999 DA - 1999// TI - Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients JO - Chest VL - 115 UR - https://doi.org/10.1378/chest.115.2.462 DO - 10.1378/chest.115.2.462 ID - Kollef1999 ER - TY - JOUR AU - Kumar, A. AU - Roberts, D. AU - Wood, K. E. AU - Light, B. AU - Parrillo, J. E. AU - Sharma, S. AU - Suppes, R. AU - Feinstein, D. AU - Zanotti, S. AU - Taiberg, L. AU - Gurka, D. AU - Kumar, A. AU - Cheang, M. PY - 2006 DA - 2006// TI - Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock JO - Crit Care Med VL - 34 UR - https://doi.org/10.1097/01.CCM.0000217961.75225.E9 DO - 10.1097/01.CCM.0000217961.75225.E9 ID - Kumar2006 ER - TY - JOUR AU - Kumar, A. AU - Ellis, P. AU - Arabi, Y. AU - Roberts, D. AU - Light, B. AU - Parrillo, J. E. AU - Dodek, P. AU - Wood, G. AU - Simon, D. AU - Peters, C. AU - Ahsan, M. AU - Chateau, D. PY - 2009 DA - 2009// TI - Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock JO - Chest VL - 136 ID - Kumar2009 ER - TY - JOUR AU - Lehmann, L. E. AU - Hunfeld, K. P. AU - Steinbrucker, M. AU - Brade, V. AU - Book, M. AU - Seifert, H. AU - Bingold, T. AU - Hoeft, A. AU - Wissing, H. AU - Stuber, F. PY - 2009 DA - 2009// TI - Improved detection of blood stream pathogens by real-time PCR in severe sepsis JO - Intensive Care Med VL - 36 UR - https://doi.org/10.1007/s00134-009-1608-z DO - 10.1007/s00134-009-1608-z ID - Lehmann2009 ER - TY - JOUR AU - Bouza, E. AU - Sousa, D. AU - Munoz, P. AU - Rodriguez-Creixems, M. AU - Fron, C. AU - Lechuz, J. G. PY - 2004 DA - 2004// TI - Bloodstream infections: a trial of the impact of different methods of reporting positive blood culture results JO - Clin Infect Dis VL - 39 UR - https://doi.org/10.1086/424520 DO - 10.1086/424520 ID - Bouza2004 ER - TY - JOUR AU - Hugonnet, S. AU - Sax, H. AU - Eggimann, P. AU - Chevrolet, J. C. AU - Pittet, D. PY - 2004 DA - 2004// TI - Nosocomial bloodstream infection and clinical sepsis JO - Emerg Infect Dis VL - 10 UR - https://doi.org/10.3201/eid1001.030407 DO - 10.3201/eid1001.030407 ID - Hugonnet2004 ER - TY - JOUR AU - Vincent, J. L. AU - Sakr, Y. AU - Sprung, C. L. AU - Ranieri, V. M. AU - Reinhart, K. AU - Gerlach, H. AU - Moreno, R. AU - Carlet, J. AU - Le Gall, J. R. AU - Payen, D. PY - 2006 DA - 2006// TI - Sepsis in European intensive care units: results of the SOAP study JO - Crit Care Med VL - 34 UR - https://doi.org/10.1097/01.CCM.0000194725.48928.3A DO - 10.1097/01.CCM.0000194725.48928.3A ID - Vincent2006 ER - TY - JOUR AU - Kost, G. J. AU - Tang, Z. AU - Tran, N. K. AU - Curd, E. E. AU - Louie, R. F. AU - Albertson, T. E. AU - Derlet, R. W. AU - Azari, R. PY - 2003 DA - 2003// TI - Economic Implications of Optimal Diagnosis and Treatment of Sepsis, Work in Progress: Marginal Penalties, Antibiotic Alterations, and Outcome Hypotheses JO - Scandinavian Journal of Clinical and Laboratory Investigation VL - 63 ID - Kost2003 ER - TY - JOUR AU - Bloos, F. AU - Hinder, F. AU - Becker, K. AU - Sachse, S. AU - Dessap, A. M. AU - Straube, E. AU - Cattoir, V. AU - Brun-Buisson, C. AU - Reinhart, K. AU - Peters, G. AU - Bauer, M. PY - 2010 DA - 2010// TI - A multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis JO - Intensive Care Med VL - 36 UR - https://doi.org/10.1007/s00134-009-1705-z DO - 10.1007/s00134-009-1705-z ID - Bloos2010 ER - TY - JOUR AU - Chan, K. Y. AU - Lam, H. S. AU - Cheung, H. M. AU - Chan, A. K. AU - Li, K. AU - Fok, T. F. AU - Ng, P. C. PY - 2009 DA - 2009// TI - Rapid identification and differentiation of Gram-negative and Gram-positive bacterial bloodstream infections by quantitative polymerase chain reaction in preterm infants JO - Crit Care Med VL - 37 UR - https://doi.org/10.1097/CCM.0b013e3181a554de DO - 10.1097/CCM.0b013e3181a554de ID - Chan2009 ER - TY - JOUR AU - Florent, M. AU - Katsahian, S. AU - Vekhoff, A. AU - Levy, V. AU - Rio, B. AU - Marie, J. P. AU - Bouvet, A. AU - Cornet, M. PY - 2006 DA - 2006// TI - Prospective evaluation of a polymerase chain reaction-ELISA targeted to Aspergillus fumigatus and Aspergillus flavus for the early diagnosis of invasive aspergillosis in patients with hematological malignancies JO - J Infect Dis VL - 193 UR - https://doi.org/10.1086/500466 DO - 10.1086/500466 ID - Florent2006 ER - TY - JOUR AU - Jordan, J. A. AU - Durso, M. B. PY - 2005 DA - 2005// TI - Real-time polymerase chain reaction for detecting bacterial DNA directly from blood of neonates being evaluated for sepsis JO - J Mol Diagn VL - 7 UR - https://doi.org/10.1016/S1525-1578(10)60590-9 DO - 10.1016/S1525-1578(10)60590-9 ID - Jordan2005 ER - TY - JOUR AU - Struelens, M. J. PY - 2010 DA - 2010// TI - Detection of microbial DNAemia: does it matter for sepsis management? JO - Intensive Care Med VL - 36 UR - https://doi.org/10.1007/s00134-009-1710-2 DO - 10.1007/s00134-009-1710-2 ID - Struelens2010 ER - TY - JOUR AU - Lehmann, L. E. AU - Alvarez, J. AU - Hunfeld, K. P. AU - Goglio, A. AU - Kost, G. J. AU - Louie, R. F. AU - Raglio, A. AU - Regueiro, B. J. AU - Wissing, H. AU - Stuber, F. PY - 2009 DA - 2009// TI - Potential clinical utility of polymerase chain reaction in microbiological testing for sepsis* JO - Crit Care Med VL - 37 UR - https://doi.org/10.1097/CCM.0b013e3181b033d7 DO - 10.1097/CCM.0b013e3181b033d7 ID - Lehmann2009 ER - TY - JOUR AU - Garnacho-Montero, J. AU - Ortiz-Leyba, C. AU - Herrera-Melero, I. AU - Aldabo-Pallas, T. AU - Cayuela-Dominguez, A. AU - Marquez-Vacaro, J. A. AU - Carbajal-Guerrero, J. AU - Garcia-Garmendia, J. L. PY - 2008 DA - 2008// TI - Mortality and morbidity attributable to inadequate empirical antimicrobial therapy in patients admitted to the ICU with sepsis: a matched cohort study JO - J Antimicrob Chemother VL - 61 UR - https://doi.org/10.1093/jac/dkm460 DO - 10.1093/jac/dkm460 ID - Garnacho-Montero2008 ER - TY - JOUR AU - Hyle, E. P. AU - Lipworth, A. D. AU - Zaoutis, T. E. AU - Nachamkin, I. AU - Bilker, W. B. AU - Lautenbach, E. PY - 2005 DA - 2005// TI - Impact of inadequate initial antimicrobial therapy on mortality in infections due to extended-spectrum beta-lactamase-producing enterobacteriaceae: variability by site of infection JO - Arch Intern Med VL - 165 UR - https://doi.org/10.1001/archinte.165.12.1375 DO - 10.1001/archinte.165.12.1375 ID - Hyle2005 ER - TY - JOUR AU - Kang, C. I. AU - Kim, S. H. AU - Park, W. B. AU - Lee, K. D. AU - Kim, H. B. AU - Kim, E. C. AU - Oh, M. D. AU - Choe, K. W. PY - 2005 DA - 2005// TI - Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome JO - Antimicrob Agents Chemother VL - 49 UR - https://doi.org/10.1128/AAC.49.2.760-766.2005 DO - 10.1128/AAC.49.2.760-766.2005 ID - Kang2005 ER - TY - JOUR AU - MacArthur, R. D. AU - Miller, M. AU - Albertson, T. AU - Panacek, E. AU - Johnson, D. AU - Teoh, L. AU - Barchuk, W. PY - 2004 DA - 2004// TI - Adequacy of early empiric antibiotic treatment and survival in severe sepsis: experience from the MONARCS trial JO - Clin Infect Dis VL - 38 UR - https://doi.org/10.1086/379825 DO - 10.1086/379825 ID - MacArthur2004 ER - TY - JOUR AU - Metan, G. AU - Uzun, O. PY - 2005 DA - 2005// TI - Impact of initial antimicrobial therapy in patients with bloodstream infections caused by Stenotrophomonas maltophilia JO - Antimicrob Agents Chemother VL - 49 UR - https://doi.org/10.1128/AAC.49.9.3980-3981.2005 DO - 10.1128/AAC.49.9.3980-3981.2005 ID - Metan2005 ER - TY - JOUR AU - Lehmann, L. E. AU - Hunfeld, K. P. AU - Emrich, T. AU - Haberhausen, G. AU - Wissing, H. AU - Hoeft, A. AU - Stuber, F. PY - 2008 DA - 2008// TI - A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples JO - Med Microbiol Immunol VL - 197 UR - https://doi.org/10.1007/s00430-007-0063-0 DO - 10.1007/s00430-007-0063-0 ID - Lehmann2008 ER - TY - JOUR AU - MacCallum, D. M. AU - Odds, F. C. PY - 2004 DA - 2004// TI - Need for early antifungal treatment confirmed in experimental disseminated Candida albicans infection JO - Antimicrob Agents Chemother VL - 48 UR - https://doi.org/10.1128/AAC.48.12.4911-4914.2004 DO - 10.1128/AAC.48.12.4911-4914.2004 ID - MacCallum2004 ER - TY - JOUR AU - Clec'h, C. AU - Timsit, J. F. AU - De Lassence, A. AU - Azoulay, E. AU - Alberti, C. AU - Garrouste-Orgeas, M. AU - Mourvilier, B. AU - Troche, G. AU - Tafflet, M. AU - Tuil, O. AU - Cohen, Y. PY - 2004 DA - 2004// TI - Efficacy of adequate early antibiotic therapy in ventilator-associated pneumonia: influence of disease severity JO - Intensive Care Med VL - 30 UR - https://doi.org/10.1007/s00134-004-2292-7 DO - 10.1007/s00134-004-2292-7 ID - Clec'h2004 ER - TY - JOUR AU - Angus, D. C. AU - Linde-Zwirble, W. T. AU - Clermont, G. AU - Ball, D. E. AU - Basson, B. R. AU - Ely, E. W. AU - Laterre, P. F. AU - Vincent, J. L. AU - Bernard, G. AU - van Hout, B. PY - 2003 DA - 2003// TI - Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis JO - Crit Care Med VL - 31 UR - https://doi.org/10.1097/00003246-200301000-00001 DO - 10.1097/00003246-200301000-00001 ID - Angus2003 ER - TY - JOUR AU - Pop-Vicas, A. E. AU - D'Agata, E. M. PY - 2005 DA - 2005// TI - The rising influx of multidrug-resistant gram-negative bacilli into a tertiary care hospital JO - Clin Infect Dis VL - 40 UR - https://doi.org/10.1086/430314 DO - 10.1086/430314 ID - Pop-Vicas2005 ER - TY - JOUR AU - Falagas, M. E. AU - Tassios, P. T. PY - 2008 DA - 2008// TI - Enhanced and earlier detection of bacteremia and fungemia by multiplex polymerase chain reaction: how much enhanced, how much earlier, and at what cost? JO - Crit Care Med VL - 36 UR - https://doi.org/10.1097/CCM.0b013e31817045e5 DO - 10.1097/CCM.0b013e31817045e5 ID - Falagas2008 ER - TY - JOUR AU - McLaughlin, A. M. AU - Hardt, J. AU - Canavan, J. B. AU - Donnelly, M. B. PY - 2009 DA - 2009// TI - Determining the economic cost of ICU treatment: a prospective "micro-costing" study JO - Intensive Care Med VL - 35 UR - https://doi.org/10.1007/s00134-009-1622-1 DO - 10.1007/s00134-009-1622-1 ID - McLaughlin2009 ER - TY - JOUR AU - Chrusch, C. A. AU - Olafson, K. P. AU - McMillan, P. M. AU - Roberts, D. E. AU - Gray, P. R. PY - 2009 DA - 2009// TI - High occupancy increases the risk of early death or readmission after transfer from intensive care JO - Crit Care Med VL - 37 UR - https://doi.org/10.1097/CCM.0b013e3181a57b0c DO - 10.1097/CCM.0b013e3181a57b0c ID - Chrusch2009 ER - TY - JOUR AU - Dellinger, R. P. AU - Carlet, J. M. AU - Masur, H. AU - Gerlach, H. AU - Calandra, T. AU - Cohen, J. AU - Gea-Banacloche, J. AU - Keh, D. AU - Marshall, J. C. AU - Parker, M. M. AU - Ramsay, G. AU - Zimmerman, J. L. AU - Vincent, J. L. AU - Levy, M. M. PY - 2004 DA - 2004// TI - Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock JO - Crit Care Med VL - 32 UR - https://doi.org/10.1097/01.CCM.0000117317.18092.E4 DO - 10.1097/01.CCM.0000117317.18092.E4 ID - Dellinger2004 ER - TY - JOUR AU - Harbarth, S. AU - Garbino, J. AU - Pugin, J. AU - Romand, J. A. AU - Lew, D. AU - Pittet, D. PY - 2003 DA - 2003// TI - Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis JO - Am J Med VL - 115 UR - https://doi.org/10.1016/j.amjmed.2003.07.005 DO - 10.1016/j.amjmed.2003.07.005 ID - Harbarth2003 ER - TY - JOUR AU - Louie, R. F. AU - Tang, Z. AU - Albertson, T. E. AU - Cohen, S. AU - Tran, N. K. AU - Kost, G. J. PY - 2008 DA - 2008// TI - Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia JO - Crit Care Med VL - 36 UR - https://doi.org/10.1097/CCM.0b013e31816f487c DO - 10.1097/CCM.0b013e31816f487c ID - Louie2008 ER - TY - JOUR AU - Karlsson, S. AU - Ruokonen, E. AU - Varpula, T. AU - Ala-Kokko, T. I. AU - Pettila, V. PY - 2009 DA - 2009// TI - Long-term outcome and quality-adjusted life years after severe sepsis JO - Crit Care Med VL - 37 UR - https://doi.org/10.1097/CCM.0b013e31819c13ac DO - 10.1097/CCM.0b013e31819c13ac ID - Karlsson2009 ER - TY - JOUR AU - Fowler, R. A. AU - Hill-Popper, M. AU - Stasinos, J. AU - Petrou, C. AU - Sanders, G. D. AU - Garber, A. M. PY - 2003 DA - 2003// TI - Cost-effectiveness of recombinant human activated protein C and the influence of severity of illness in the treatment of patients with severe sepsis JO - J Crit Care VL - 18 UR - https://doi.org/10.1016/j.jcrc.2003.08.009 DO - 10.1016/j.jcrc.2003.08.009 ID - Fowler2003 ER - TY - JOUR AU - Manns, B. J. AU - Lee, H. AU - Doig, C. J. AU - Johnson, D. AU - Donaldson, C. PY - 2002 DA - 2002// TI - An economic evaluation of activated protein C treatment for severe sepsis JO - N Engl J Med VL - 347 UR - https://doi.org/10.1056/NEJMsa020969 DO - 10.1056/NEJMsa020969 ID - Manns2002 ER -