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Table 1 Evolution of some blood and urine parameters in 10 patients with mild hyponatremia treated by 45 g urea/daily at least during three days

From: Treatment of euvolemic hyponatremia in the intensive care unit by urea

 

Day -1

Day 0

Day 1

Day 2

S Urea (mg/dL) N < 40

25 (± 10.1)

25 (± 9.5)

60 (± 25.9)*

67 ± 29.7*

S Creat (mg/dL) N < 1.1

0.5 (± 0.1)

0.5 (± 0.1)

0.5 (± 0.1)

0.5 (± 0.1)

S Na (mmol/L)

133 (± 1.3)

130 (± 1.8)

132 (± 3.7)

136 (± 5.0)*

S K (mmol/L)

4 (± 0.4)

4 (± 0.3)

4 (± 0.3)

4 (± 0.3)

U Osm (mosmol/kg)

587 (± 153.3)

623 (± 136.5)

637 (± 112.2)

690 (± 122.0)

U Urea (mg/dL)

938 (± 511.4)

1031 (± 476.8)

1806 (± 461.6)*

2187 (± 534.1)*

U Creat (mg/dL)

44 (± 25.5)

45 (± 23.0)

30 (± 15.0)

29 (± 16.3)

U Na (mmol/L)

127 (± 32.9)

139 (± 43.2)

112 (± 44.0)

93 (± 39.0)

FE.Na (%) N < 1.5%

1.2 (± 0.6)

1.2 (± 0.5)

1.51 (± 0.9)

1.31 (± 0.6)

FE.Osm (%) N < 3%

2.38 (± 0.6)

2.45 (± 0.5)

3.99 (± 1.8)*

4.62 (± 1.6)*

  1. *P < 0.01 compared to day 0.
  2. S, serum; U, urine; FE.Na, fractional sodium excretion; FE.Osm, fractional osmolytes excretion.
  3. To convert S urea (mg/dl) in BUN (mg/dl) multiplied by 0.467.