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Table 1 Evolution of some blood and urine parameters in 10 patients with mild hyponatremia treated by 45 g urea/daily at least during three days

From: Treatment of euvolemic hyponatremia in the intensive care unit by urea

  Day -1 Day 0 Day 1 Day 2
S Urea (mg/dL) N < 40 25 (± 10.1) 25 (± 9.5) 60 (± 25.9)* 67 ± 29.7*
S Creat (mg/dL) N < 1.1 0.5 (± 0.1) 0.5 (± 0.1) 0.5 (± 0.1) 0.5 (± 0.1)
S Na (mmol/L) 133 (± 1.3) 130 (± 1.8) 132 (± 3.7) 136 (± 5.0)*
S K (mmol/L) 4 (± 0.4) 4 (± 0.3) 4 (± 0.3) 4 (± 0.3)
U Osm (mosmol/kg) 587 (± 153.3) 623 (± 136.5) 637 (± 112.2) 690 (± 122.0)
U Urea (mg/dL) 938 (± 511.4) 1031 (± 476.8) 1806 (± 461.6)* 2187 (± 534.1)*
U Creat (mg/dL) 44 (± 25.5) 45 (± 23.0) 30 (± 15.0) 29 (± 16.3)
U Na (mmol/L) 127 (± 32.9) 139 (± 43.2) 112 (± 44.0) 93 (± 39.0)
FE.Na (%) N < 1.5% 1.2 (± 0.6) 1.2 (± 0.5) 1.51 (± 0.9) 1.31 (± 0.6)
FE.Osm (%) N < 3% 2.38 (± 0.6) 2.45 (± 0.5) 3.99 (± 1.8)* 4.62 (± 1.6)*
  1. *P < 0.01 compared to day 0.
  2. S, serum; U, urine; FE.Na, fractional sodium excretion; FE.Osm, fractional osmolytes excretion.
  3. To convert S urea (mg/dl) in BUN (mg/dl) multiplied by 0.467.