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Table 3 Area under the curve for each biomarker as a predictor of severe sepsis and death

From: The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis

  Outcome
  Severe Sepsis Death
Biomarker AUC 95% CI AUC 95% CI
sFlt-1 0.82* 0.76 to 0.88 0.91* 0.87 to 0.95
PAI-1 0.69 0.62 to 0.76 0.74 0.60 to 0.88
Eselectin 0.71 0.64 to 0.78 0.65 0.49 to 0.82
Icam 0.61 0.53 to 0.69 0.72 0.57 to 0.87
Vcam 0.60 0.52 to 0.69 0.57 0.35 to 0.79
  1. *the area under the curve for sFlt-1 in predicting both severe sepsis (includes patients with septic shock) and mortality was significantly greater than all other AUC values, P < 0.01.