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Figure 6 | Critical Care

Figure 6

From: Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery

Figure 6

Fate of intravenously injected recombinant human IL-6 in pre-renal azotemia, ischemic AKI, and bilateral nephrectomy. A total of 200 ng of recombinant human (h) IL-6 was administered by tail vein injection five hours after vehicle-injection (Veh), furosemide injection/pre-renal azotemia (Pre), sham operation (Sham), ischemic AKI (AKI), or after bilateral nephrectomy. Urine was collected for one hour and serum was collected at one hour. (A) Serum human IL-6 is elevated in mice with ischemic AKI and bilateral nephrectomy versus vehicle injection, pre-renal azotemia, and sham operation (*P < 0.01 versus vehicle injection, pre-renal azotemia, and sham operation, n = 4; **P < 0.05 versus ischemic AKI). (B) Urine human IL-6 is increased in mice with ischemic AKI versus vehicle injection, pre-renal azotemia, and sham operation (***P < 0.01 versus vehicle injection, pre-renal azotemia, and sham operation, n = 4 to 5). (Mice with bilateral nephrectomy are anuric; therefore, no urine values are reported for this group).

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