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Figure 3 | Critical Care

Figure 3

From: Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery

Figure 3

Mouse model of pre-renal azotemia and ischemic AKI. Prerenal azotemia after furosemide injection is characterized by increased urine output (A), increased total body weight loss (B), increased hematocrit (C), and normal creatinine (D) compared to vehicle injection, sham operation, and ischemic AKI (urine output was determined at two hours; total body weight loss, hematocrit, and creatinine were determined at six hours). BUN (E) is increased in both pre-renal azotemia and ischemic AKI (BUN was determined at six hours). Two hours post-ischemic AKI (F), patchy necrosis with areas of normal proximal tubules in intact brush borders (arrows) is present; at six hours post ischemic AKI (G), proximal tubule necrosis is wide spread. Renal histology is normal after furosemide injection (H).

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