Skip to main content

Table 4 Study drug safety and tolerability

From: Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial

  Placebo
N= 25
Heparin
N= 25
P value
Percentage of scheduled doses withheld 3.8 ± 9.2 5.8 ± 9.5 0.5
Reasons for withholding    
   Blood-stained sputum 1 (4) 6 (24) 0.1
   Prolonged APTT 1 (4) 3 (12) 0.6
   Suspected HIT 0 1 (4) 1
   Confirmed HIT 1 (4) 0 1
   Invasive procedure 3 (12) 0 0.2
   Other 4 (16) 2 (8) 0.7
Percentage of days during study period with    
   Blood-stained sputum 31 ± 28 41 ± 39 0.3
   Frank blood in sputum 2.5 ± 9 7.0 ± 21 0.3
   Purulent sputuma 62 ± 25 61 ± 35 1
Red cell transfusion    
   Volume transfused per day (mls) 0 (0-57) 0 (0-85) 0.9
   Patients transfused 10 (40) 7 (28) 0.4
   Abnormal APTTb (> 40 seconds) 5/17 (29) 11/19 (58) 0.08
  1. aDenotes sputum reported as yellow, green, dirty, or purulent. bPatients on therapeutic heparin were excluded from this analysis. Values other than P values are presented as mean ± standard deviation, as median (interquartile range), or as number (percentage). APPT, activated partial thromboplastin time; HIT, heparin-induced thrombocytopenia.