Table 1 Comparison between GLP-1, GLP-1 analogues and DPP-4 inhibitors
| Â | GLP-1 | GLP-1 analogues | DPP-4 inhibitors |
|---|---|---|---|
Name(s) | GLP-1-(7-36)NH2 | Exenatide | Sitagliptin |
| Â | Â | Liraglutide | Vildagliptin |
| Â | Â | Â | Saxagliptin |
Administration | Intravenous | Subcutaneous | Oral |
Studied in the critically ill patient | Yes | Yes | No |
Current cost | Prohibitive | Expensive | Expensive |
Availability | Limited | Yes | Yes |
Half-life | 1 to 2 minutes | 2 to 15 hours | 2 to 14 hours |
Additional effects mediated via inactive GLP-1 | Yes | No | No |
Nausea | Yes | Yes | No |
Weight | Loss | Loss | Weight neutral |
Gastric emptying | Slows | Slows | Minimal, if any, effect |