Sublingual microcirculatory changes during high-volume hemofiltration in hyperdynamic septic shock patients

Table 2 Evolution of microcirculatory scores and hemodynamic and perfusion parameters during the study

Parameter	Baseline	After 12 hours of HVHF	6 hours after HVHF
MAP, mm Hg	67.5 ± 4.3	74.5 ± 6.8^a	76.0 ± 9.4^a
Norepinephrine, μg/kg per min	0.49 ± 0.21	0.44 ± 0.45	0.26 ± 0.38
CI, L/min per m²	4.06 ± 1.11	3.68 ± 1.36	3.55 ± 1.12
SmvO₂, percentage	72.4 ± 1.7	71.4 ± 7.0	76.1 ± 6.0
Lactate, mmol/L	5.38 ± 2.99	3.66 ± 2.39^a	3.64 ± 3.89^a
IDO₂, mL/min per m²	543 ± 211	483 ± 350	475 ± 173
IVO₂, mL/min per m²	137 ± 63	135 ± 101	108 ± 40
O₂ER, percentage	26 ± 12.3	27.8 ± 0.7	23.1 ± 6.0
SVRI, dyne-s/cm⁵ per m²	1,027 ± 268	1,373 ± 408^b	1,432 ± 375^b
Hemoglobin, g/dL	10.1 ± 1.4	10.2 ± 2	10.2 ± 1.3
Core temperature, °C	38.1 ± 1	37.2 ± 0.9	37.5 ± 1.1
SOFA score	12.8 ± 1.7	13.1 ± 2.1	12.4 ± 2.5
TVD, n/mm	13.1 ± 1.9	13.6 ± 3.3	14.2 ± 3.8
PVD, n/mm	9.6 ± 2.5	11.1 ± 3.0	12.1 ± 4.3
PPV, percentage	73.6 ± 15.6	81.7 ± 13.3^c	83.2 ± 14.7^c
MFI^d	2.15 (1.64-2.28)	2.5 (1.96-2.7)^b	2.5 (2.31-2.63)^b
Het MFI^d	0.44 (0.36-0.47)	0.4 (0.12-0.65)	0.29 (0.18-0.32)

^aP < 0.05 versus baseline; ^bP < 0.01 versus baseline; ^cP < 0.06 versus baseline; ^ddata are presented as mean ± standard deviation or as median and 25th-75th percentiles. CI, cardiac index; Het MFI, heterogeneity of microvascular flow index; HVHF, high-volume hemofiltration; IDO₂, oxygen delivery index; IVO₂, oxygen consumption index; MAP, mean arterial pressure; MFI, microvascular flow index; n/mm, number of vessels per millimeter; O₂ER, oxygen extraction ratio; PPV, proportion of perfused vessels; PVD, perfused vascular density; SmvO₂, mixed venous oxygen saturation; SOFA, Sequential Organ Failure Assessment; SVRI, systemic vascular resistance index; TVD, total vascular density.

ISSN: 1364-8535