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Table 1 Clinical and laboratory characteristics of the patients

From: Host adaptive immunity deficiency in severe pandemic influenza

  MV (n= 12) NMV (n= 7)
Gender (M/F) 7/5 2/5
Age 45.6 (10.3) 38.5 (13.1)
Ethnicity Caucasian (10/12), gipsy (1/12), India (1/12) Caucasian (5/7), Black (1/7), Magreb (1/7)
BMI 27.7 (6.3) 27.1 (5.5)
Pandemic influenza vaccine 0/12 0/7
Chronic respiratory disease 2/12 1/7
Chronic renal disease 1/12 2/7
Cardiovascular disease 1/12 0/7
Neurological disease 3/12 1/7
Gastrointestinal disease 2/12 0/7
Cancer 0/12 1/7
Obesity (BMI > 30) 3/12 2/7
Diabetes 1/12 0/7
Pregnancy 1/12 (32 weeks) 2/7 (31 and 27 weeks)
Dyslipemia 2/12 0/7
Alcoholism 1/12 2/7
Smoker 6/12 3/7
Fatal outcome/survivors 7/5 0/7
Duration of symptoms at ICU admission 5.7 (2.3) 6.5 (1.2)
O2 saturation at admission (room air) 88.0 (10.8) 95.3 (2.7)
Days at ICU 17.5 (22.1) 4.6 (2.3)
Days at hospital 14.2 (7.4) 11.8 (6.1)
Days since onset to intubation 6 (2.4) n.a
Oseltamivir* 12/12 7/7
Duration of symptoms before oseltamivir 5.3 (2.3) 6.1 (1.2)
Days with oseltamivir (days) 8.7 (5.0) 7.1 (2.4)
Steroids at sampling 5/12 4/7
Infiltrates in chest X-ray 12/12 7/7
Progression of infiltrates to all 4 quadrants on chest X-ray 6/12 1/7
Bacterial/fungal Superinfection [Microbe, sample (resp culture-RC; hemoculture-HC), days from ICU admission to first bacterial isolation, days from symptoms onset to first bacterial isolation] 1. S. aureus, A. fumigatus, RC, E. faecalis, HC, 2,10 2. S. marcenses, HC, 7,10 3. P. aeruginosa, RC, 5,14 4. C. albicans, S. Marcenses, RC, 43,52 5. A. fumigatus, C. Albicans, RC, 6, 12 n.a
  MV early MV late NMV early NMV late
SOFA score 4.0 (3.4) 7.5 (3.1) 3.4 (2.1) 3.5 (2.8)
Creatinine (mg/dl) 0.7 (0.3) 0.7 (0.4) 1.7 (2.8) 1.7 (1.6)
AST (U/liter) 63.5 (34.6) 73.7 (37.3) 73.8 (39.9) 61.8 (78.3)
ALT (U/liter) 26.8 (16.1) 58.8 (38.9) 75.6 (59.9) 76.6 (86.7)
CPK (IU/liter) 221.2 (290.8) 713.0 (640.5) 449.0 (697.8) 152.7 (171.6)
Leucocytes/mm3 2594.6 (2907.5) 7923.6 (7100.4) 2917.3 (3723.0) 3524.4 (5208.6)
Neutrophils (%) 52.4 (37.9) 73.3 (27.3) 38.6 (42.9) 34.8 (38.1)
Lymphocytes x103 /mm3 2.2 (2.4) 0.8 (0.6) 0.6 (0.2) 1.1 (0.5)
  1. Data are shown as means with SD where appropriate. N.a., not applicable. R.C., respiratory culture; HC: hemoculture. *Oseltamivir was administered orally or by nasogastric route in accordance with CDC recommendations [31].