Table 1 Clinical and laboratory characteristics of the patients
From: Host adaptive immunity deficiency in severe pandemic influenza
MV (n= 12) | NMV (n= 7) | |||
|---|---|---|---|---|
Gender (M/F) | 7/5 | 2/5 | ||
Age | 45.6 (10.3) | 38.5 (13.1) | ||
Ethnicity | Caucasian (10/12), gipsy (1/12), India (1/12) | Caucasian (5/7), Black (1/7), Magreb (1/7) | ||
BMI | 27.7 (6.3) | 27.1 (5.5) | ||
Pandemic influenza vaccine | 0/12 | 0/7 | ||
Chronic respiratory disease | 2/12 | 1/7 | ||
Chronic renal disease | 1/12 | 2/7 | ||
Cardiovascular disease | 1/12 | 0/7 | ||
Neurological disease | 3/12 | 1/7 | ||
Gastrointestinal disease | 2/12 | 0/7 | ||
Cancer | 0/12 | 1/7 | ||
Obesity (BMI > 30) | 3/12 | 2/7 | ||
Diabetes | 1/12 | 0/7 | ||
Pregnancy | 1/12 (32 weeks) | 2/7 (31 and 27 weeks) | ||
Dyslipemia | 2/12 | 0/7 | ||
Alcoholism | 1/12 | 2/7 | ||
Smoker | 6/12 | 3/7 | ||
Fatal outcome/survivors | 7/5 | 0/7 | ||
Duration of symptoms at ICU admission | 5.7 (2.3) | 6.5 (1.2) | ||
O2 saturation at admission (room air) | 88.0 (10.8) | 95.3 (2.7) | ||
Days at ICU | 17.5 (22.1) | 4.6 (2.3) | ||
Days at hospital | 14.2 (7.4) | 11.8 (6.1) | ||
Days since onset to intubation | 6 (2.4) | n.a | ||
Oseltamivir* | 12/12 | 7/7 | ||
Duration of symptoms before oseltamivir | 5.3 (2.3) | 6.1 (1.2) | ||
Days with oseltamivir (days) | 8.7 (5.0) | 7.1 (2.4) | ||
Steroids at sampling | 5/12 | 4/7 | ||
Infiltrates in chest X-ray | 12/12 | 7/7 | ||
Progression of infiltrates to all 4 quadrants on chest X-ray | 6/12 | 1/7 | ||
Bacterial/fungal Superinfection [Microbe, sample (resp culture-RC; hemoculture-HC), days from ICU admission to first bacterial isolation, days from symptoms onset to first bacterial isolation] | 1. S. aureus, A. fumigatus, RC, E. faecalis, HC, 2,10 2. S. marcenses, HC, 7,10 3. P. aeruginosa, RC, 5,14 4. C. albicans, S. Marcenses, RC, 43,52 5. A. fumigatus, C. Albicans, RC, 6, 12 | n.a | ||
MV early | MV late | NMV early | NMV late | |
SOFA score | 4.0 (3.4) | 7.5 (3.1) | 3.4 (2.1) | 3.5 (2.8) |
Creatinine (mg/dl) | 0.7 (0.3) | 0.7 (0.4) | 1.7 (2.8) | 1.7 (1.6) |
AST (U/liter) | 63.5 (34.6) | 73.7 (37.3) | 73.8 (39.9) | 61.8 (78.3) |
ALT (U/liter) | 26.8 (16.1) | 58.8 (38.9) | 75.6 (59.9) | 76.6 (86.7) |
CPK (IU/liter) | 221.2 (290.8) | 713.0 (640.5) | 449.0 (697.8) | 152.7 (171.6) |
Leucocytes/mm3 | 2594.6 (2907.5) | 7923.6 (7100.4) | 2917.3 (3723.0) | 3524.4 (5208.6) |
Neutrophils (%) | 52.4 (37.9) | 73.3 (27.3) | 38.6 (42.9) | 34.8 (38.1) |
Lymphocytes x103 /mm3 | 2.2 (2.4) | 0.8 (0.6) | 0.6 (0.2) | 1.1 (0.5) |