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Table 1 Summary of published studies for idiopathic pulmonary fibrosis patients in the intensive care unit.

From: Clinical review: Idiopathic pulmonary fibrosis acute exacerbations - unravelling Ariadne's thread

Study Time frame Patients Ventilated patients Biopsy proven IPF exacerbations Therapya Ventilator settings NIV ICU mortality Hospital mortality
Stern et al. [29] 1991-1999 23 23 15/23 (65%) 16 91% TV 8-13 mL/kg NR 22/23 (96%) 22/23 (96%)
Blivet et al. [28] 1989-1998 15 15 7/15 (47%) 6 100% NR 5 11/15 (73%) 13/15 (87%)
Saydain et al. [31] 1995-2000 38 19 18/38 (47%) 15/38 61% NR 7 13/19 (68%) 23/38 (61%)b
Al-Hameed and Sharma [32] 1988-2000 25 25 8/25 (32%) 25 100% PEEP 7 cm H2O 3 21/25 (84%) 24/25 (96%)
Kim et al. [4] 1990-2003 10 9 7/9 (78%) 9 100% NR NR (7/9) 78% (7/9) 78%
Rangappa and Moran [34] 1996-2006 24 19 33% 8 71% NR   (16/24) 67% (22/24) 92%
Fernández-Pérez et al. [64] 2002-2006 30
(14 S, 16 M)
30 17/30 (57%) NR 30% TV 7 mL/kg NR NR (11/16) 69%
Mollica et al. [59] 2000-2007 34 34
(15 INV, 19 NIV)
16/34 (47%) 22 100% TV 7.5 mL/kg 19 100% for INV, 73% for NIV (29/34) 85%c
  1. All studies were single-center retrospective. aTherapy consisted of corticosteroids plus immunosuppressants. bNinety-two percent of the survivors died at a median of 2 months after hospital discharge. cFour out of five survivors died shortly after hospital discharge. ICU, intensive care unit; INV, invasive ventilation; IPF, idiopathic pulmonary fibrosis; M, medical; NIV, non-invasive ventilation; NR, not reported; PEEP, positive end-expiratory pressure; S, surgical; TV, tidal volume.