Skip to main content


Figure 8 | Critical Care

Figure 8

From: Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in mice

Figure 8

Flagellin activates pro-apoptotic signaling in mouse tissues. Cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP; immunoblotting) in mouse organs at baseline (time 0), and at one and three hours after flagellin (5 μg). Caspase-3 and PARP were cleaved slightly at one hour in the liver and lung, and strongly at three hours in the gut. No cleavage of caspase-3 was noted in the kidney, which disclosed a discrete cleavage of PARP at one hour. Procaspase-3 and uncleaved PARP did not change over time, except in the gut where both decreased after three hours. Blots are representative of at least three independent experiments.

Back to article page