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Table 4 Effects on base excess and chloride concentrations from different clinical studies

From: A balanced view of balanced solutions

Study

Setting

Infusion strategy

Volumes infused during study period (ml)

Minimal value in base excess (mmol/l)

Maximal change in chloride (mmol/l)

Boldt and colleagues [18]

Abdominal surgery

Balanced group

Ā 

< 1a

+3a

Ā Ā 

ā€ƒā€ƒā€ƒHES 130/0.42

3,866 Ā± 1,674

Ā Ā 
Ā Ā 

ā€ƒā€ƒā€ƒModified RL

5,966 Ā± 1,202

Ā Ā 
Ā Ā 

Saline-based group

Ā 

-5a

+8a

Ā Ā 

ā€ƒā€ƒā€ƒHES 130/0.42

3,533 Ā± 1,302

Ā Ā 
Ā Ā 

ā€ƒā€ƒā€ƒIsotonic saline

5,333 Ā± 1,063

Ā Ā 

Kulla and colleagues [21]

Abdominal surgery

Balanced

Ā 

-1.8

+3

Ā Ā 

ā€ƒā€ƒā€ƒHES 130/0.42

1,923 Ā± 989

Ā Ā 
Ā Ā 

ā€ƒā€ƒā€ƒModified RL

4,268 Ā± 999

Ā Ā 
Ā Ā 

Saline-based

Ā 

-4.2

+5

Ā Ā 

ā€ƒā€ƒā€ƒHES 130/0.42

1,828 Ā± 522

Ā Ā 
Ā Ā 

ā€ƒā€ƒā€ƒModified saline

4,490 Ā± 1,126

Ā Ā 

Boldt and colleagues [19]

Cardiac surgery

Balanced

Ā 

-1.2

Not reported

Ā Ā 

ā€ƒā€ƒā€ƒHES 130/0.42

2,750 Ā± 640

Ā Ā 
Ā Ā 

ā€ƒā€ƒā€ƒModified RL

5,200 Ā± 610

Ā Ā 
Ā Ā 

Saline-based

Ā 

-4.4

Not reported

Ā Ā 

ā€ƒā€ƒā€ƒHES 130

2,820 Ā± 550

Ā Ā 
Ā Ā 

ā€ƒā€ƒā€ƒIsotonic saline

5,150 Ā± 570

Ā Ā 

Boldt and colleagues [20]

Cardiopulmonary bypass

Balanced

Ā 

0a

Not reported

Ā Ā 

ā€ƒā€ƒā€ƒHES 130/0.42

3,090 Ā± 540

Ā Ā 
Ā Ā 

ā€ƒā€ƒā€ƒModified RL

4,010 Ā± 410

Ā Ā 
Ā Ā 

Saline-based

Ā 

-6a

Not reported

Ā Ā 

ā€ƒā€ƒā€ƒ5% albumin

3,110 Ā± 450

Ā Ā 
Ā Ā 

ā€ƒā€ƒā€ƒIsotonic saline

5,450 Ā± 560

Ā Ā 

Boldt and colleagues [22]

Cardiopulmonary bypass

Balanced

Ā 

-1a

Not reported

Ā Ā 

ā€ƒā€ƒā€ƒHES 130/0.40

2,950 Ā± 530

Ā Ā 
Ā Ā 

ā€ƒā€ƒā€ƒModified RL

5,090 Ā± 750

Ā Ā 
Ā Ā 

Saline-based

Ā 

-5a

Not reported

Ā Ā 

ā€ƒā€ƒā€ƒ5% albumin

3,050 Ā± 560

Ā Ā 
Ā Ā 

ā€ƒā€ƒā€ƒIsotonic saline

5,050 Ā± 680

Ā Ā 
  1. HES, hydroxyethyl starch; RL, Ringer's lactate. aValues estimated from figures reported in the article