Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: a retrospective analysis

Table 6 Multivariate backward stepwise logistic regression analysis of the increased mortality in open-heart procedures

		B	SE	Sig.	Odds ratio (OR)	95.0% CI for OR
						Lower	Upper
Step 1	Age	-0.043	0.018	0.019	0.958	0.924	0.993
	CPB time	0.012	0.004	0.002	1.012	1.004	1.020
	EURO Score II	0.278	0.063	0.000	1.321	1.168	1.493
	Creatinine preop	0.146	0.207	0.481	1.157	0.772	1.734
	Hemoglobin preop	-0.148	0.125	0.238	0.863	0.675	1.103
	Antifibrinolytic	-0.788	0.437	0.071	0.455	0.193	1.070
	Constant	-0.940	1.959	0.631	0.391
Step 2	Age	-0.041	0.018	0.023	0.959	0.926	0.994
	CPB time	0.012	0.004	0.001	1.012	1.005	1.020
	EURO Score II	0.276	0.062	0.000	1.318	1.167	1.489
	Hemoglobin preop	-0.175	0.119	0.142	0.840	0.665	1.060
	Antifibrinolytic	-0.832	0.431	0.054	0.435	0.187	1.013
	Constant	-0.534	1.866	0.775	0.586
Step 3	Age	-0.044	0.018	0.014	0.957	0.923	0.991
	CPB Time	0.011	0.004	0.003	1.011	1.004	1.019
	EURO Score II	0.300	0.060	0.000	1.350	1.200	1.518
	Antifibrinolytic	-0.947	0.424	0.025	0.388	0.169	0.890
	Constant	-2.554	1.302	0.050	0.078

CI, confidence interval; CPB, cardiopulmonary bypass; OR, odds ratio; SD, standard deviation; SEM, standard error of the mean.

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