Table 5 Blood loss, transfusion, and coagulation-related data for patients receiving aprotinin and tranexamic acid

Blood loss first 6 h (mL)

All patients

230

338

366

492

< 0.01

Open-heart procedures

229

260

459

616

< 0.01

Blood loss first 24 h (mL)

All patients

437

669

613

705

< 0.01

Open-heart procedures

431

431

707

881

< 0.01

Blood loss 48 h (mL)

All patients

72

159

118

223

< 0.01

Open-heart procedures

77

177

137

284

0.02

Packed red blood surgery (units)

All patients

0.5

1.2

0.7

1.5

0.02

Open-heart procedures

0.6

1.2

0.8

1.4

0.19

Packed red blood first 24 h (units)

All patients

0.7

2.1

1.3

2.4

< 0.01

Open-heart procedures

0.8

1.8

1.9

2.9

< 0.01

FFP surgery (units)

All patients

0.3

1.1

0.4

1.4

0.09

Open-heart procedures

0.5

1.5

0.8

1.6

0.13

FFP first 24 h (units)

All patients

0.8

4.4

1.6

5.0

< 0.01

Open-heart procedures

1.0

3.2

2.8

7.3

< 0.01

Platelet concentrates surgery (units)

All patients

0.1

0.5

0.2

0.6

< 0.01

Open-heart procedures

0.1

0.5

0.3

0.7

< 0.01

Platelet concentrates first 24 h (units)

All patients

0.2

0.8

0.4

1.2

< 0.01

Open-heart procedures

0.2

0.9

0.6

1.7

< 0.01

PPSB (IU)

All patients

14.1

154.7

30.4

186.1

0.16

Open-heart procedures

19.5

168.0

57.1

269.9

0.13

AT III (IU)

All patients

23.5

200.5

41.8

275.8

0.26

Open-heart procedures

30.2

237.3

38.1

237.1

0.78

F XIII (IU)

All patients

9.0

130.0

14.2

161.8

0.60

Open-heart procedures

11.6

120.3

23.8

244.0

0.55

aFVII (IU)

All patients

3.1

46.8

5.0

39.1

0.52

Open-heart procedures

3.4

36.8

13.7

65.1

0.07

Desmopressin (μg/kg)

All patients

0.3

2.4

0.2

1.9

0.58

Open-heart procedures

0.5

3.2

0.4

2.5

0.71

Rethoracotomy (bleeding)

All patients

N

13

23

< 0.01

Open-heart procedures

7

15

< 0.01

All patients

% in group

2.4%

6.9%

Open-heart procedures

3.3%

14.3%