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Table 3 Biochemical data of patients receiving aprotinin and tranexamic acid

From: Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: a retrospective analysis

 

Aprotinin

Tranexamic acid

 
 

Mean

SD

Mean

SD

P

Creatinine after surgery (mg/dL)

     

All patients

1.1

0.7

1.2

0.8

0.02

Open-heart procedures

1.08

0.50

1.30

0.73

< 0.01

Creatinine POD 1 (mg/dL)

     

All patients

1.5

5.3

2.2

14.0

0.29

Open-heart procedures

1.37

1.83

1.42

0.65

0.77

CK after surgery (U/mL)

     

All patients

521

635

474

782

0.33

Open-heart procedures

521

605

589

1307

0.53

CK-MB after surgery (U/mL)

     

All patients

59

64

54

69

0.27

Open-heart procedures

59

64

77

109

0.39

CK POD 1 (U/mL)

     

All patients

1013

1496

878

1131

0.16

Open-heart procedures

1032

1462

914

1224

0.48

CK-MB POD 1 (U/mL)

     

All patients

55

69

52

80

0.51

Open-heart procedures

59

64

67

103

0.42

WBC after surgery (/nL)

     

All patients

12.6

5.5

12.5

5.4

0.80

Open-heart procedures

13.6

5.7

13.8

6.3

0.74

WBC POD 1 (/nL)

     

All patients

14.0

4.4

13.8

6.9

0.63

Open-heart procedures

14.4

4.4

13.4

4.2

0.04

Hemoglobin after surgery (g/dL)

     

All patients

10.2

1.2

10.5

7.3

0.27

Open-heart procedures

10.1

1.4

11.1

12.9

0.26

Hemoglobin POD 1 (g/dL)

     

All patients

10.4

1.2

10.3

3.8

0.77

Open-heart procedures

10.3

1.1

10.7

6.6

0.44

Platelets after surgery (/nL)

     

All patients

144

50

153

56

0.01

Open-heart procedures

143

55

149

62

0.35

Platelets POD 1 (/nL)

     

All patients

158

55

160

57

0.53

Open-heart procedures

147

59

145

59

0.75

PT ratio after surgery (%)

     

All patients

65

10

64

10

0.03

Open-heart procedures

64

11

61

10

< 0.01

PT ratio POD 1 (%)

     

All patients

75

12

74

11

0.04

Open-heart procedures

73

13

71

13

0.12

aPTT after surgery (s)

     

All patients

51.0

16.7

41.0

14.5

< 0.01

Open-heart procedures

53.6

19.0

43.4

21.0

< 0.01

aPTT POD 1 (s)

     

All patients

44.0

15.1

41.2

10.3

< 0.01

Open-heart procedures

46.6

17.9

42.7

12.2

0.05

AT III after surgery (%)

     

All patients

67

12

68

13

0.37

Open-heart procedures

69

12

69

15

0.67

AT III POD 1 (%)

     

All patients

76

14

74

14

0.31

Open-heart procedures

78

13

75

15

0.34

  1. AT III, antithrombin; CK, creatinine kinase; CK-MB, creatinine kinase isoenzyme MB; POD, postoperative day; PT, prothrombin ratio; PTT, partial thromboplastin time; SD, standard deviation; WBC, white blood cell count.
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