Table 4 Intravenous treatment of hypophosphatemia
From: Treatment of hypophosphatemia in the intensive care unit: a review
Author [ref.] | Year | Serum phosphate (mmol/L) | Dose | Speed | Efficacy | Complications/safety |
|---|---|---|---|---|---|---|
Brown et al. [61] | 2006 | 0.73-0.96 | 0.32 mmol/kg | 7.5 mmol/h | No significant increase in iP | Considered safe |
| Ā | Ā | 0.51-0.72 | 0.64 mmol/kg | 7.5 mmol/h | iP normalized in 59% | Considered safe |
| Ā | Ā | <0.50 | 1 mmol/kg | 7.5 mmol/h | iP normalized in 60% | Considered safe |
Taylor et al. [62] | 2004 | 0.55-0.70 | 0.2 mmol/kg | 33 Ī¼mol/kg/h | iP normalized in 76% (all patients) | Considered safe |
| Ā | Ā | 0.32-0.55 | 0.4 mmol/kg | 67 Ī¼mol/kg/h | Ā | Considered safe |
| Ā | Ā | <0.32 | 0.6 mmol/kg | 100 Ī¼mol/kg/h | Ā | Considered safe |
Charron et al. [63] | 2003 | 0.40-0.65 | 30 mmol | 15 mmol/h | Equally effective | Mild hyperphosphatemia and mild hyperkalemia |
| Ā | Ā | Ā | 30 mmol | 7.5 mmol/h | Ā | Ā |
| Ā | Ā | <0.40 | 45 mmol | 15 mmol/h | Equally effective | Ā |
| Ā | Ā | Ā | 45 mmol | 7.5 mmol/h | Ā | Ā |
Perreault et al. [64] | 1997 | 0.40-0.80 | 15 mmol | 5 mmol/h | iP normalized in 81.5% | Considered safe |
| Ā | Ā | <0.40 | 30 mmol | 10 mmol/h | iP normalized in 30% | Considered safe |
Rosen et al. [65] | 1995 | 0.50-0.65 | 15 mmol | 7.5 mmol/h | iP normalized in 100% | Considered safe |
Bollaert et al. [66] | 1995 | <0.65 | 20 mmol | 20 mmol/h | iP normalized in 80% | Considered safe Mild hypocalcemia |
Kruse et al. [67] | 1992 | <0.80 | 20-40 mmol | 20 mmol/h | mean iP rose from 0.65 to 1.0 mmol/L | considered safe Mild hypocalcemia |