Figure 6

Factor XIII depletion in antibiotic treated pneumococcal pneumonia. Factor XIII levels 48 hours after induction of pneumococcal pneumonia in wild-type (WT) mice (white white, n = 8) and mice heterozygous (light grey white, n = 8) or homozygous (dark grey white, n = 7) for the factor V Leiden mutation treated intraperitoneally with ceftriaxone 24 hours after infection. Data are expressed as box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile and largest observation. The mean intensity in WT mice was used as reference value (100%). ** represents statistical significance as compared with WT (P < 0.01, Mann Whitney U test).