Figure 3

Bacterial outgrowth in untreated pneumococcal pneumonia. Bacterial outgrowth in (a) lung, (b) blood and (c) spleen 24 and 48 hours after induction of pneumococcal pneumonia in wild-type mice (white white, n = 8) and mice heterozygous (light grey white, n = 8) or homozygous (dark grey white, n = 8) for the factor V Leiden mutation. Data are expressed as box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile and largest observation. The dotted horizontal line represents the detection limit. There were no statistical differences between the groups at either time point. CFU, colony forming units.