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Table 2 Hemodynamics, electrolytes, respiratory parameters lactate, ALT and Cystatin C levels and urine output of mechanically ventilated mice

From: Simvastatin attenuates ventilator-induced lung injury in mice

  6 h Vent. 6 h Vent. + Simva
  mean SD mean SD
Na + (mmol/l) 159 5 159 4
K + (mmol/l) 4.7 0.5 4.7 0.4
Cl - (mmol/l) 124 4 125 4
Ca 2+ (mmol/l) 1.29 0.06 1.30 0.05
ph 7.45 0.08 7.51 0.08
p a CO 2 (mmHg) 42.2 4.8 34.5 10.0
SBE (mmol/l) 3.0 2.1 3.5 1.7
HCO 3 - (mmol/l) 26.7 2.6 26.6 2.7
Lactate (mmol/l) 1.5 0.4 1.6 0.3
ALT (U/l) 30 12 21 4
Cystatin C (ng/ml) 443 64 479 65
MAP 0 h (mmHg) 91 7 87 10
MAP 1 h (mmHg) 74 7 72 7
MAP 2 h (mmHg) 68 5 70 6
MAP 3 h (mmHg) 70 6 70 7
MAP 4 h (mmHg) 68 5 69 7
MAP 5 h (mmHg) 69 6 67 7
MAP 6 h (mmHg) 73 8 72 10
Urine Output 6 h (μl) 908 294 669 207
  1. After six hours of mechanical ventilation of simvastatin (6 h Vent. + Simva) or sham treated mice (6 h Vent.) urine output was assed and electrolyte, blood gas, lactate, Cystatin C and ALT analysis was performed from arterial blood or plasma respectively. Systemic mean arterial blood pressure (MAP) was measured continuously.