Simvastatin improved oxygenation in VILI. (a) Peripheral Oxygen Saturation (SpO2) was monitored continuously and (b) P/F ratio was assessed at the end of the 6 h ventilation period in simvastatin (6 h Vent. + Simva) or sham (6 h Vent.) treated mice. Simvastatin treatment prevented the decline of SpO2 and improved oxygenation in VILI. (a: 6 h Vent. N = 8; 6 h Vent. + Simva n = 10; b: 6 h Vent. N = 7; 6 h Vent. + Simva n = 9; *P < 0.05).