Early administration of norepinephrine increases cardiac preload and cardiac output in septic patients with life-threatening hypotension

Table 6 Hemodynamic variables in the subgroups of patients with left ventricular ejection fraction ≤45% and an achieved mean arterial pressure inferior (n = 17) or superior (n = 17) to the median value (74 mm Hg)

	Achieved MAP < 75 mm Hg		Achieved MAP ≥75 mm Hg
	Before NE (introduction/increase)	After NE (introduction/increase)	Before NE (introduction/increase)	After NE (introduction/increase)
Heart rate, beats/min	100 ± 16	96 ± 17	92 ± 18	91 ± 17
MAP, mm Hg	49 ± 8	68 ± 4^a	58 ± 8	82 ± 7^a
DAP, mm Hg	36 ± 6	48 ± 7^a	40 ± 8	56 ± 9^a
CI, L/min/m²	2.7 ± 0.9	3.0 ± 1.0^a	3.2 ± 0.8	3.4 ± 0.8
SVI, ml/m²	28 ± 11	33 ± 13^a	35 ± 10	38 ± 10
GEDVI, ml/m²	660 ± 167	770 ± 185^a	737 ± 157	766 ± 201
CFI, per min	3.9 ± 1.5	4.0 ± 1.5	4.4 ± 1.2	4.6 ± 1.4
SVRI, dynes/sec/cm⁵/m²	1,654 ± 639	1,993 ± 709^a	1,523 ± 355	2,057 ± 527^a

CFI, cardiac function index; CI, cardiac index; DAP, diastolic arterial pressure; GEDVI, global end-diastolic volume index; HR, heart rate; MAP, mean arterial pressure; NE, norepinephrine; SVI, stroke volume index; SVRI, index of systemic vascular resistance.
^aP < 0.05 vs. before norepinephrine.

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