Early administration of norepinephrine increases cardiac preload and cardiac output in septic patients with life-threatening hypotension

Table 5 Hemodynamic variables in the subgroups of patients with left ventricular ejection fraction >45% and an achieved mean arterial pressure either inferior (n = 36) or superior (n = 35) to the median value (75 mm Hg)

	Achieved MAP <75 mm Hg		Achieved MAP ≥75 mm Hg
	Before NE (introduction/increase)	After NE (introduction/increase)	Before NE (introduction/increase)	After NE (introduction/increase)
Heart rate, beats/min	105 ± 22	104 ± 21	93 ± 23	95 ± 21
MAP, mm Hg	52 ± 7	69 ± 5^a	56 ± 6	83 ± 6^a
DAP, mm Hg	37 ± 7	48 ± 7^a	39 ± 4	56 ± 8^a
CI, L/min/m²	3.2 ± 1.1	3.6 ± 1.1^a	3.5 ± 1.1	4.1 ± 1.3^a
SVI, ml/m²	32 ± 13	36 ± 13^a	40 ± 12	46 ± 15^a
GEDVI, ml/m²	674 ± 133	731 ± 157^a	687 ± 147	729 ± 160^a
CFI, per min	4.8 ± 1.7	5.0 ± 1.6	5.3 ± 1.7	5.8 ± 1.7^a
SVRI, dynes/sec/cm⁵/m²	1,435 ± 487	1,639 ± 486^a	1,405 ± 503	1,725 ± 577^a

CFI, cardiac function index; CI, cardiac index; DAP, diastolic arterial pressure; GEDVI, global end-diastolic volume index; HR, heart rate; MAP, mean arterial pressure; NE, norepinephrine; SVI, stroke volume index; SVRI, index of systemic vascular resistance.
^aP < 0.05 vs. before norepinephrine.

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